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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F05%3A00002012%21RIV06-MZ0-15110___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Aberantní exprese růstových faktorů a jejich receptorů stromálními buňkami může být důležitým faktorem podporujícím růst solidních nádorů. Cílem studie bylo ověřit, zda bazický fibroblastový růstový faktor (bFGF) a růstový faktor krevních destiček (PDEGF) jsou zapojeny do vzájemných interakcí mezi nádorovým a stromálním mikroprostředím u primárních maligních melanomů. Výsledky naznačují, že bFGF a PDEGF participují na progresi maligního melanomu. Background: Aberrant expression of either growth factors or growth factor-receptors by stromal cells can be an important factor promoting the growth of solid tumours. It may also affect differentiation of malignant cells and support tumour spread. The aim of the present study was to investigate the hypothesis that basic-fibroblast growth factor (bFGF) and platelet-derived growth factor (PDEGF) may be involved in tumour-stromal microenvironment interactions in primary malignant melanomas. Materials and Methods: PDEGF and bFGF expression in malignant cells and surrounding stromal elements was assessed using indirect immunohistochemistry. Results: It was confirmed that PDEGF can be involved in the reciprocal interactions between tumour cells and stroma, including aberrant angiogenesis. Interestingly, bFGF was present both in malignant melanoma lesions and benign nevi accompanied by different intracellular localisation of the protein, suggesting its implication in regulation of nevus cell proliferation an Background: Aberrant expression of either growth factors or growth factor-receptors by stromal cells can be an important factor promoting the growth of solid tumours. It may also affect differentiation of malignant cells and support tumour spread. The aim of the present study was to investigate the hypothesis that basic-fibroblast growth factor (bFGF) and platelet-derived growth factor (PDEGF) may be involved in tumour-stromal microenvironment interactions in primary malignant melanomas. Materials and Methods: PDEGF and bFGF expression in malignant cells and surrounding stromal elements was assessed using indirect immunohistochemistry. Results: It was confirmed that PDEGF can be involved in the reciprocal interactions between tumour cells and stroma, including aberrant angiogenesis. Interestingly, bFGF was present both in malignant melanoma lesions and benign nevi accompanied by different intracellular localisation of the protein, suggesting its implication in regulation of nevus cell proliferation an
dcterms:title
Molecular changes in PDEGF and bFGF in malignant melanomas in relation to the stromal microenvironment Molecular changes in PDEGF and bFGF in malignant melanomas in relation to the stromal microenvironment Molekulární změny v PDEGF a bFGF u maligních melanomů ve vztahu ke stromálnímu mikroprostředí
skos:prefLabel
Molecular changes in PDEGF and bFGF in malignant melanomas in relation to the stromal microenvironment Molekulární změny v PDEGF a bFGF u maligních melanomů ve vztahu ke stromálnímu mikroprostředí Molecular changes in PDEGF and bFGF in malignant melanomas in relation to the stromal microenvironment
skos:notation
RIV/61989592:15110/05:00002012!RIV06-MZ0-15110___
n3:strany
4299-4304
n3:aktivita
n7:P
n3:aktivity
P(1A8245)
n3:cisloPeriodika
6B
n3:dodaniDat
n13:2006
n3:domaciTvurceVysledku
n4:1708678 n4:2619725 n4:1915908 n4:2955601 n4:9582320
n3:druhVysledku
n6:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
530996
n3:idVysledku
RIV/61989592:15110/05:00002012
n3:jazykVysledku
n17:eng
n3:klicovaSlova
malignant melanoma; microenvironment; PDEGF; bFGF
n3:klicoveSlovo
n9:PDEGF n9:microenvironment n9:malignant%20melanoma n9:bFGF
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[75D909813738]
n3:nazevZdroje
Anticancer Research
n3:obor
n16:FO
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
8
n3:projekt
n10:1A8245
n3:rokUplatneniVysledku
n13:2005
n3:svazekPeriodika
25
n3:tvurceVysledku
Sedláková, E. Zálešák, B. Brychtová, Světlana Beneš, P. Fiurášková, Michala Kolář, Zdeněk Tichý, Martin Hlobilková, Alice
s:issn
0250-7005
s:numberOfPages
6
n18:organizacniJednotka
15110