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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F05%3A00002005%21RIV06-MZ0-15110___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Monocyte chemoattractant protein (MCP)-1 is the keychemokine in the process of atheroslerotic vascularinflammation. Examining already reported associationbetween coronary artery disease (CAD) and the SNP A/Gin the MCP-1 gene (position −2518), 139 Czech patientswith CAD manifested as myocardial infarction (MI) and359 unrelated healthy control (C) subjects were genotypedby PCR-SSP. Genotype and allele frequencies werenot different in MI and C groups (allele G: MI, 20.5%; C,23.8%, OR = 0.8, P > 0.05). No differences were detectedwhen the patients were subdivided based on sex or theage of MI first occurrence. Further, no relationship wasobserved between circulating MCP-1 levels and carriageof the G allele. The data do not support a role for the MCP-1 −2518 single nucleotide polymorphism in susceptibilityto CAD manifested by myocardial infarction. Práce studuje souvislost polymorfismu genu pro chemokin MCP-1 (MCP-1-2518) ve vztahu k predispozici k aterosklerotickému postižení věnčitých tepen a infarktu myokardu. Asociační studie na 139 pacientech a 359 kontrolních jedincích nezjistila souvislost mezi uvedeným polymorfismem a infarktem myokardu v české populaci. Monocyte chemoattractant protein (MCP)-1 is the keychemokine in the process of atheroslerotic vascularinflammation. Examining already reported associationbetween coronary artery disease (CAD) and the SNP A/Gin the MCP-1 gene (position −2518), 139 Czech patientswith CAD manifested as myocardial infarction (MI) and359 unrelated healthy control (C) subjects were genotypedby PCR-SSP. Genotype and allele frequencies werenot different in MI and C groups (allele G: MI, 20.5%; C,23.8%, OR = 0.8, P > 0.05). No differences were detectedwhen the patients were subdivided based on sex or theage of MI first occurrence. Further, no relationship wasobserved between circulating MCP-1 levels and carriageof the G allele. The data do not support a role for the MCP-1 −2518 single nucleotide polymorphism in susceptibilityto CAD manifested by myocardial infarction.
dcterms:title
Jednonukleotidový polymorfismus MCP-1-2518 (A/G) nesouvisí s infarktem myokardu v české populaci The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
skos:prefLabel
The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population Jednonukleotidový polymorfismus MCP-1-2518 (A/G) nesouvisí s infarktem myokardu v české populaci The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
skos:notation
RIV/61989592:15110/05:00002005!RIV06-MZ0-15110___
n3:strany
315-318
n3:aktivita
n16:P
n3:aktivity
P(NI7308)
n3:cisloPeriodika
5
n3:dodaniDat
n14:2006
n3:domaciTvurceVysledku
n4:3292053 n4:7444885 n4:5149517 n4:2265397
n3:druhVysledku
n18:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
529146
n3:idVysledku
RIV/61989592:15110/05:00002005
n3:jazykVysledku
n17:eng
n3:klicovaSlova
MCP-1; polymorphism
n3:klicoveSlovo
n7:MCP-1 n7:polymorphism
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[16D9674FBAA2]
n3:nazevZdroje
International Journal of Immunonegetics
n3:obor
n13:EC
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:projekt
n15:NI7308
n3:rokUplatneniVysledku
n14:2005
n3:svazekPeriodika
32
n3:tvurceVysledku
Petřek, Martin Lukl, Jan Drábek, Jiří Arakelyan, A. Mrázek, František Petřková, Jana Čermáková, Z.
s:issn
1744-3121
s:numberOfPages
4
n8:organizacniJednotka
15110