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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F05%3A00001985%21RIV06-MSM-15110___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Bylo nalezeno, že hladina adiponektinu (AN) v plasmě je vyšší u mírných konzumentů alkoholu ve srovnání s abstinenty, dokonce i po korekci na BMI. Konzumenti alkoholu trpící jaterní steatosou měli positivní korelaci mezi koncentracemi AN, laboratorními markery onemocnění jater a TNF-alfa. Tato korelace nebyla nalezena u abstinentů trpících steatosou.Toto naznačujem že alkohol může modulovat inhibiční vliv TNF-alfa na produkci AN, a takto zvyšovat jeho koncentraci v plasmě. Moderate alcohol consumption is associated with increased insulin sensitivity and a reduced risk for type 2 diabetes. An important endogenous mediator of insulin sensitivity is adiponectin (AN), an adipokine that displays numerous antiatherogenic, antidiabetogenic and antiinflammatory effects. Recently, acute increase in alcohol consumption has been shown to be associated with increase in plasma adiponectin and, concomitantly, insulin sensitivity. Whether chronic alcohol consumption predicts an increase in plasma AN and whether this is independent of adiposity, markers of liver dysfunction, and plasma adipokines such as tumor necrosis factor (TNF)-alpha is not known. We, therefore, investigated these relationships in 75 men who were diagnosed with liver steatosis using ultrasound/liver biopsy. We examined 75 men, who were diagnosed for having liver steatosis (ultrasound/liver biopsy). Each filled in a questionnaire on alcohol intake. Subjects were divided into two subgroups according to alcohol histor Moderate alcohol consumption is associated with increased insulin sensitivity and a reduced risk for type 2 diabetes. An important endogenous mediator of insulin sensitivity is adiponectin (AN), an adipokine that displays numerous antiatherogenic, antidiabetogenic and antiinflammatory effects. Recently, acute increase in alcohol consumption has been shown to be associated with increase in plasma adiponectin and, concomitantly, insulin sensitivity. Whether chronic alcohol consumption predicts an increase in plasma AN and whether this is independent of adiposity, markers of liver dysfunction, and plasma adipokines such as tumor necrosis factor (TNF)-alpha is not known. We, therefore, investigated these relationships in 75 men who were diagnosed with liver steatosis using ultrasound/liver biopsy. We examined 75 men, who were diagnosed for having liver steatosis (ultrasound/liver biopsy). Each filled in a questionnaire on alcohol intake. Subjects were divided into two subgroups according to alcohol histor
dcterms:title
High adiponectin and TNF-alpha levels in moderate drinkers suffering from liver steatosis: comparison with non drinkers suffering from similar hepatopathy High adiponectin and TNF-alpha levels in moderate drinkers suffering from liver steatosis: comparison with non drinkers suffering from similar hepatopathy Vysoké hladiny adiponektinu a TNF-alfa u mírných konzumentů alkoholu trpících steatosou: srovnání s abstinenty trpícími podobnou hepatopathií
skos:prefLabel
Vysoké hladiny adiponektinu a TNF-alfa u mírných konzumentů alkoholu trpících steatosou: srovnání s abstinenty trpícími podobnou hepatopathií High adiponectin and TNF-alpha levels in moderate drinkers suffering from liver steatosis: comparison with non drinkers suffering from similar hepatopathy High adiponectin and TNF-alpha levels in moderate drinkers suffering from liver steatosis: comparison with non drinkers suffering from similar hepatopathy
skos:notation
RIV/61989592:15110/05:00001985!RIV06-MSM-15110___
n5:strany
93-99
n5:aktivita
n12:Z
n5:aktivity
Z(MSM6198959216)
n5:cisloPeriodika
1
n5:dodaniDat
n8:2006
n5:domaciTvurceVysledku
n15:7572085
n5:druhVysledku
n6:J
n5:duvernostUdaju
n10:S
n5:entitaPredkladatele
n16:predkladatel
n5:idSjednocenehoVysledku
523247
n5:idVysledku
RIV/61989592:15110/05:00001985
n5:jazykVysledku
n17:eng
n5:klicovaSlova
Adiponectin; moderate drinking; alcohol; diabetes; adipokines
n5:klicoveSlovo
n7:alcohol n7:adipokines n7:diabetes n7:moderate%20drinking n7:Adiponectin
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[00197AF38D5E]
n5:nazevZdroje
Biomedical Papers
n5:obor
n9:CE
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
5
n5:rokUplatneniVysledku
n8:2005
n5:svazekPeriodika
149
n5:tvurceVysledku
Stejskal, David Kolář, Vladimír Fanfrdlová, Gabriela Bartek, Josef Růžička, Viktor
n5:zamer
n13:MSM6198959216
s:issn
1213-8118
s:numberOfPages
7
n18:organizacniJednotka
15110