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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F05%3A00001983%21RIV06-MSM-15110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
ABSTRACT. Preventive vaccination by a hsp90-expressing DNA vaccine and recombinant hsp90 proteinvaccine, both derived from the Candida albicans hsp90 using BALB-c mouse model of systemic candidiasis,was performed. Hsp90 mRNA was cloned from a clinical isolate of C. albicans, converted to cDNA andcloned into vaccination plasmid pVAX1. Two methods of DNA application were tested: intramuscular (i.m.)and intradermal (i.d.) injection. Recombinant protein was applied by i.d. injection with Freund's adjuvant;the control groups received PBS or Freund's adjuvant only. Mice were vaccinated and after 19 d re-vaccinated.After 3 weeks, the mice were challenged with the live C. albicans in a dose of 5 x 106 CFU per mouse.After the challenge, the mice vaccinated i.d. with DNA vaccine survived for 39 and 64 % longer comparedto those receiving Freund's adjuvant and/or PBS, respectively. The i.m. application of the DNA vaccine didnot provide any significant protectivity. The serum level of anti-candida-h Byla provedena preventivní vakcinace experimentálních BALB/c myší DNA vakcínou exprimující hsp90 protein z Candida albicans a vakcinace tímto proteinem připraveným rekombinantní technologií. Efektivita byla testována na modelu systémové kandidózy. Z mikrobiologicky ověřeného kmene C. albicans byla izolována mRNA hsp90, přepsána do cDNA a klonována do vakcinačního plasmidu pVAX1. Byly použity dvě metody aplikace DNA: intramuskulární (i.m.) nebo intradermální (i.d.) injekce. Rekombinantní protein byl injikován ve Freundově adjuvans i.d.; kontrolní skupině byl aplikován PBS nebo Freundovo adjuvans. Myši byly dvakrát vakcinovány s odstupem 19 dní. Tři týdny po druhé dávce byly myši i.v. infikovány 5x10exp6 CFU živých C. albicans. I.d. DNA vakcinace prodloužila přežívání myší vůči kontrolní skupině s Freundovým adjuvans o 39% a vůči skupině s PBS o 64%. I.m. DNA vakcinace nebyla spojena s průkazem protektivity. Sérové hladiny IgG imunoglobulinů specificky reagujících s hsp90 C. albicans korelovaly s přežív ABSTRACT. Preventive vaccination by a hsp90-expressing DNA vaccine and recombinant hsp90 proteinvaccine, both derived from the Candida albicans hsp90 using BALB-c mouse model of systemic candidiasis,was performed. Hsp90 mRNA was cloned from a clinical isolate of C. albicans, converted to cDNA andcloned into vaccination plasmid pVAX1. Two methods of DNA application were tested: intramuscular (i.m.)and intradermal (i.d.) injection. Recombinant protein was applied by i.d. injection with Freund's adjuvant;the control groups received PBS or Freund's adjuvant only. Mice were vaccinated and after 19 d re-vaccinated.After 3 weeks, the mice were challenged with the live C. albicans in a dose of 5 x 106 CFU per mouse.After the challenge, the mice vaccinated i.d. with DNA vaccine survived for 39 and 64 % longer comparedto those receiving Freund's adjuvant and/or PBS, respectively. The i.m. application of the DNA vaccine didnot provide any significant protectivity. The serum level of anti-candida-h
dcterms:title
Comparison of Protective Effect of Protein and DNA Vaccines hsp90 in Murine Model of Systemic Candidiasis Comparison of Protective Effect of Protein and DNA Vaccines hsp90 in Murine Model of Systemic Candidiasis Srovnání protektivního efektu proteinové a DNA vakcín hsp90 na modelu systémové kandidózy experimentálních myší.
skos:prefLabel
Comparison of Protective Effect of Protein and DNA Vaccines hsp90 in Murine Model of Systemic Candidiasis Srovnání protektivního efektu proteinové a DNA vakcín hsp90 na modelu systémové kandidózy experimentálních myší. Comparison of Protective Effect of Protein and DNA Vaccines hsp90 in Murine Model of Systemic Candidiasis
skos:notation
RIV/61989592:15110/05:00001983!RIV06-MSM-15110___
n3:strany
77-82
n3:aktivita
n13:Z
n3:aktivity
Z(MSM 151100002)
n3:cisloPeriodika
1
n3:dodaniDat
n17:2006
n3:domaciTvurceVysledku
n6:5903793 n6:1587307 n6:4854454 n6:9582320 n6:3350819
n3:druhVysledku
n15:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
515903
n3:idVysledku
RIV/61989592:15110/05:00001983
n3:jazykVysledku
n8:eng
n3:klicovaSlova
DNA; vaccine; hsp90; candida
n3:klicoveSlovo
n12:hsp90 n12:vaccine n12:DNA n12:candida
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[9F415DA46A05]
n3:nazevZdroje
Folia Microbiologica
n3:obor
n18:EC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n17:2005
n3:svazekPeriodika
50
n3:tvurceVysledku
Kolář, Zdeněk Růžičková, Katharine Wudattu, Nalini K. Kafková, Leona Raška, Milan Šebestová, Martina Běláková, Jana Weigl, Evžen
n3:zamer
n11:MSM%20151100002
s:issn
0015-5632
s:numberOfPages
6
n4:organizacniJednotka
15110