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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F05%3A00001919%21RIV06-MSM-15110___
rdf:type
n18:Vysledek skos:Concept
dcterms:description
Microtubule disruptors, widely known as antimitotics, have broad applications in human medicine, especially as anti-neoplastic agents. They are subject to biotransformation within human body frequently involving cytochromes P450. Therefore antimitotics are potential culprits of drug-drug interactions on the level of activity as well as expression of cytochromes P450. This review discusses the effects of four well-known natural antimitotics: colchicine, taxol (paclitaxel), vincristine, and vinblastine, and a synthetic microtubule disruptor nocodazole on transcriptional activity of glucocorticoid and aryl hydrocarbon receptors. It appears that microtubules disarray restricts the signaling by these two nuclear receptors regardless of cell cycle phase. Consequently, intact microtubules play an important role in the regulation of expression of cytochromes P450, which are under direct or indirect control of the two nuclear receptors. Microtubule disruptors, widely known as antimitotics, have broad applications in human medicine, especially as anti-neoplastic agents. They are subject to biotransformation within human body frequently involving cytochromes P450. Therefore antimitotics are potential culprits of drug-drug interactions on the level of activity as well as expression of cytochromes P450. This review discusses the effects of four well-known natural antimitotics: colchicine, taxol (paclitaxel), vincristine, and vinblastine, and a synthetic microtubule disruptor nocodazole on transcriptional activity of glucocorticoid and aryl hydrocarbon receptors. It appears that microtubules disarray restricts the signaling by these two nuclear receptors regardless of cell cycle phase. Consequently, intact microtubules play an important role in the regulation of expression of cytochromes P450, which are under direct or indirect control of the two nuclear receptors. Disruptory mikrotubulů, známější pod názvem antimitotika, mají široké uplatnění v humánní medicíně, nejčastěji jako antineoplastika. Tyto látky podléhají v lidském těle biotransformaci, která je obvykle katalyzována cytochromy P450. Proto jsou antimitotika možnou příčinou mezilékových interakcí jak na úrovni aktivity, tak exprese cytochromů P450. Toto review diskutuje účinky čtyř nejznámějších antimitotik přírodního původu: kolchicinu, taxolu (paklitaxelu), vinkristinu a vinblastinu, a také syntetického disruptoru mikrotubulů nokodazolu, na transkripční aktivitu glukokortikoidního a aryl hydrokarbonového receptoru. Literární data naznačují, že porušení mikrotubulů limituje signalizaci prováděnou těmito dvěma receptory a to nezávisle na fázi buněčného cyklu. Z toho vyplývá, že mikrotubuly hrají důležitou úlohu v regulaci exprese cytochromů P450, které jsou pod přímou či nepřímou kontrolou těchto dvou nukleárních receptorů.
dcterms:title
Disruptory mikrotubulů a jejich interakce s biotransformačními enzymy Microtubule disruptors and their interaction with biotransformation enzymes Microtubule disruptors and their interaction with biotransformation enzymes
skos:prefLabel
Disruptory mikrotubulů a jejich interakce s biotransformačními enzymy Microtubule disruptors and their interaction with biotransformation enzymes Microtubule disruptors and their interaction with biotransformation enzymes
skos:notation
RIV/61989592:15110/05:00001919!RIV06-MSM-15110___
n3:strany
213-216
n3:aktivita
n17:Z n17:P
n3:aktivity
P(GP303/04/P074), Z(MSM6198959216)
n3:cisloPeriodika
2
n3:dodaniDat
n7:2006
n3:domaciTvurceVysledku
n9:8069239 n9:1030957
n3:druhVysledku
n19:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
530205
n3:idVysledku
RIV/61989592:15110/05:00001919
n3:jazykVysledku
n10:eng
n3:klicovaSlova
Antimitotic drugs; Drug metabolism; Cytochromes P450; Nuclear receptors; Gene expression
n3:klicoveSlovo
n4:Nuclear%20receptors n4:Cytochromes%20P450 n4:Drug%20metabolism n4:Antimitotic%20drugs n4:Gene%20expression
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[37A519E74E96]
n3:nazevZdroje
Biomedical Papers
n3:obor
n8:CE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n14:GP303%2F04%2FP074
n3:rokUplatneniVysledku
n7:2005
n3:svazekPeriodika
149
n3:tvurceVysledku
Dvořák, Zdeněk Modrianský, Martin
n3:zamer
n16:MSM6198959216
s:issn
1213-8118
s:numberOfPages
4
n11:organizacniJednotka
15110