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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F04%3A00006054%21RIV09-MZ0-15110___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Phosphatase and tension homology deleted on chromosome ten (PTEN) is a tumor suppressor gene with protein and lipid phosphatase activity frequently altered in several types of human cancers. Herein, we demonstrate the effect of transfected wild type (wt) PTEN and its mutants (mt) L57W, H123Y, G129R that have lost lipid and protein phosphatase activity; and G129E characterized by loss of only lipid phosphatase activity, during the cell cycle and on apoptosis. Nádorový supresor PTEN blokuje buněčný cyklus na přechodu fáze G1-S u prostatických nádorových linií. Pro funkci PTEN v regulaci buněčného cyklu je nutná jeho fosfatázová aktivita. PTEN hraje důležitou úlohu v negativní regulaci PI3K/Akt dráhy. Phosphatase and tension homology deleted on chromosome ten (PTEN) is a tumor suppressor gene with protein and lipid phosphatase activity frequently altered in several types of human cancers. Herein, we demonstrate the effect of transfected wild type (wt) PTEN and its mutants (mt) L57W, H123Y, G129R that have lost lipid and protein phosphatase activity; and G129E characterized by loss of only lipid phosphatase activity, during the cell cycle and on apoptosis.
dcterms:title
The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines Nádorový supresorový gen PTEN hraje úlohu v regulaci buněčného cyklu a apoptózy v prostatických nádorových linií. The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines
skos:prefLabel
Nádorový supresorový gen PTEN hraje úlohu v regulaci buněčného cyklu a apoptózy v prostatických nádorových linií. The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines The Tumor Suppressor Gene PTEN Plays a Role in Cell Cycle Regulation and Apoptosis in Prostate Cancer Cell Lines
skos:notation
RIV/61989592:15110/04:00006054!RIV09-MZ0-15110___
n4:aktivita
n5:P n5:Z
n4:aktivity
P(NC6779), Z(MSM 151100001)
n4:dodaniDat
n7:2009
n4:domaciTvurceVysledku
n11:2673223 n11:9582320 n11:8028869 n11:4445082 n11:2619725
n4:druhVysledku
n21:C
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
590966
n4:idVysledku
RIV/61989592:15110/04:00006054
n4:jazykVysledku
n18:eng
n4:klicovaSlova
PTEN/MMAC; phosphatase; cell cycle
n4:klicoveSlovo
n9:cell%20cycle n9:PTEN%2FMMAC n9:phosphatase
n4:kontrolniKodProRIV
[278017B521C1]
n4:nazevZdroje
Hormonal Carcinogenesis - Proceeding of the 4th International Symposium
n4:obor
n20:FD
n4:pocetDomacichTvurcuVysledku
5
n4:pocetStranKnihy
7
n4:pocetTvurcuVysledku
7
n4:projekt
n6:NC6779
n4:rokUplatneniVysledku
n7:2004
n4:tvurceVysledku
Guldberg, Per Šváchová, Michaela Knillová, Jana Pimrová, Eva Řiháková, Petra Kolář, Zdeněk Hlobilková, Alice
n4:zamer
n17:MSM%20151100001
s:numberOfPages
7
n15:hasPublisher
Springer-Verlag
n19:isbn
0-387-23783-6
n10:organizacniJednotka
15110