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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F04%3A00002040%21RIV06-MZ0-15110___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Exogenní hormonální manipulace může mít vliv na změnu fyziologické cyklické struktury děložní sliznice. Tato studie hodnotí vliv orálně podávané náhrady estrogen-progesteronu na chování receptorů estrogenu a progesteronu a na hladinu apoptózy v sekrečním endometriu nahrazených cyklů v porovnání s přirozenými cykly u stejného pacienta. Objective: Exogenous hormonal manipulation may alter physiological cyclic pattern of endometrium. This article evaluates the effect of oral estrogen-progesterone substitution on the expression of estrogen and progesterone receptors and the level of apoptosis in the secretory endometrium of substituted cycles by comparison with natural cycles in the same patient.Methods: Serum levels of estradiol (E2), SHBG and progesterone (P) were determined and bioptic samples of endometrium were taken on the 5th and 7th day of luteal phase in 26 infertile women who entered the assisted reproduction program first in a spontaneous and later in an estrogen-progestagen substituted cycle. E and P receptors (ER and PR) were estimated by immunostaining and image analysis in stroma and glandular epithelium. The level of apoptosis was evaluated by the TUNEL assay. Wilcoxon matched-pairs test was used for the statistical analysis of data.Results: The mean serum levels of E2, SHBG and P were higher in substituted cycles; Objective: Exogenous hormonal manipulation may alter physiological cyclic pattern of endometrium. This article evaluates the effect of oral estrogen-progesterone substitution on the expression of estrogen and progesterone receptors and the level of apoptosis in the secretory endometrium of substituted cycles by comparison with natural cycles in the same patient.Methods: Serum levels of estradiol (E2), SHBG and progesterone (P) were determined and bioptic samples of endometrium were taken on the 5th and 7th day of luteal phase in 26 infertile women who entered the assisted reproduction program first in a spontaneous and later in an estrogen-progestagen substituted cycle. E and P receptors (ER and PR) were estimated by immunostaining and image analysis in stroma and glandular epithelium. The level of apoptosis was evaluated by the TUNEL assay. Wilcoxon matched-pairs test was used for the statistical analysis of data.Results: The mean serum levels of E2, SHBG and P were higher in substituted cycles;
dcterms:title
Vliv estrogen-progestinové substituce na expresi estrogenových a progesteronových receptorů a apoptózu v lidském endometriu THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM
skos:prefLabel
THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM Vliv estrogen-progestinové substituce na expresi estrogenových a progesteronových receptorů a apoptózu v lidském endometriu
skos:notation
RIV/61989592:15110/04:00002040!RIV06-MZ0-15110___
n3:strany
22-28
n3:aktivita
n8:P
n3:aktivity
P(NH6611)
n3:cisloPeriodika
2
n3:dodaniDat
n11:2006
n3:domaciTvurceVysledku
n6:7105053 n6:4607120 n6:7925662 n6:4452240 n6:4891228
n3:druhVysledku
n18:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
567386
n3:idVysledku
RIV/61989592:15110/04:00002040
n3:jazykVysledku
n10:eng
n3:klicovaSlova
estradiol; progesterone; hormonal substitution; apoptosis; steroid receptors
n3:klicoveSlovo
n5:progesterone n5:steroid%20receptors n5:estradiol n5:hormonal%20substitution n5:apoptosis
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[6F5CF0E202F7]
n3:nazevZdroje
Acta Medica Martiniana
n3:obor
n13:FK
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
7
n3:projekt
n17:NH6611
n3:rokUplatneniVysledku
n11:2004
n3:svazekPeriodika
4
n3:tvurceVysledku
Kubínyiová, Michaela Kršková, Milena Březinová, Jana Oborná, Ivana Havelka, Pavel Fingerová, Helena Lichnovský, Václav
s:issn
1335-8421
s:numberOfPages
7
n14:organizacniJednotka
15110