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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F04%3A00001965%21RIV06-MSM-15110___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
In last few years, numerous groups of proteins participating in the regulation of cell proliferation, differentiation and death during ontogenesis have been described. In this study we compared the occurrence of Bcl-2, p53 and myc protein families with the level of proliferative activity and apoptosis during development of duodenal epithelium. Paraffin embedded tissues of eight human embryos and foetuses aged from the 6th -18th week of IUD were used. For the detection of apoptotic cells the TUNEL method was performed, the proliferative marker PCNA and all the proteins studied were detected by means of indirect three-step immunohistochemical method.In the 6th and 8th week of intrauterine development we observed isolated TUNEL positive epithelial cells only and this was accompanied by the disperse presence of PCNA as well as by all the studied proteins: Bcl-2, Bax, Bcl-XL, c-myc, N-myc, p53, p63 and p73. In the early foetal period of duodenal development we registered changes in PCNA and TUNEL positiv In last few years, numerous groups of proteins participating in the regulation of cell proliferation, differentiation and death during ontogenesis have been described. In this study we compared the occurrence of Bcl-2, p53 and myc protein families with the level of proliferative activity and apoptosis during development of duodenal epithelium. Paraffin embedded tissues of eight human embryos and foetuses aged from the 6th -18th week of IUD were used. For the detection of apoptotic cells the TUNEL method was performed, the proliferative marker PCNA and all the proteins studied were detected by means of indirect three-step immunohistochemical method.In the 6th and 8th week of intrauterine development we observed isolated TUNEL positive epithelial cells only and this was accompanied by the disperse presence of PCNA as well as by all the studied proteins: Bcl-2, Bax, Bcl-XL, c-myc, N-myc, p53, p63 and p73. In the early foetal period of duodenal development we registered changes in PCNA and TUNEL positiv V posledních letech bylo popsáno několik skupin proteinů zasahujících do regulace buněčné proliferace , diferenciace a buněčné smrti během ontogeneze. V naší studii jsme srovnávali výskyt některých proteinů přináležejících k Bcl-2, p53 a myc rodinám s proliferační aktivitou a úrovní apoptózy během vývoje epitelu lidského duodena.
dcterms:title
The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium Výskyt proteinů rodiny c-myc, p53 a Bcl-2 v časných fázích vývoje epitelu duodena.
skos:prefLabel
The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium The occurrence of c-myc, p53 and Bcl-2 family proteins in the early phase of development of duodenal epithelium Výskyt proteinů rodiny c-myc, p53 a Bcl-2 v časných fázích vývoje epitelu duodena.
skos:notation
RIV/61989592:15110/04:00001965!RIV06-MSM-15110___
n3:strany
229-232
n3:aktivita
n17:Z
n3:aktivity
Z(MSM 151100001)
n3:cisloPeriodika
2
n3:dodaniDat
n8:2006
n3:domaciTvurceVysledku
n9:9376100 n9:3698815
n3:druhVysledku
n14:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
577361
n3:idVysledku
RIV/61989592:15110/04:00001965
n3:jazykVysledku
n10:eng
n3:klicovaSlova
Bcl-2 family; p53 family; myc; apoptosis; embryo; duodenum
n3:klicoveSlovo
n6:duodenum n6:Bcl-2%20family n6:apoptosis n6:myc n6:embryo n6:p53%20family
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[6ABB382A27AB]
n3:nazevZdroje
Biomedical Papers
n3:obor
n18:EA
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n8:2004
n3:svazekPeriodika
148
n3:tvurceVysledku
Erdösová, Běla Holinka, M. Vrchovecký, J. Kylarová, Dana
n3:zamer
n5:MSM%20151100001
s:issn
1213-8118
s:numberOfPages
4
n7:organizacniJednotka
15110