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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F03%3A00007270%21RIV09-MSM-15110___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
Interspecies differences in glycosidation potential in mammalian tissues represent a factor contributing to ambiguity when endobiotic and/or xenobiotic metabolic pathways are extrapolated from animals to man. Using the TLC/autoradiographic technique, we conducted an in vitro investigation involving mouse, rat, monkey, as well as human liver and kidney microsomes to evaluate their glycoconjugation potential towards (3)H-labeled, purine-derived selective inhibitors of cyclin-dependent kinases such as olomoucine, bohemine, roscovitine, 6-(2-hydroxybenzyl)amino-2-(1-hydroxymethyl-2-methylpropyl)amino-9-isopropylpurine (compound A-4), and 6-(3-hydroxybenzyl)amino-2-[(1(R/S)-hydroxymethyl)propyl]amino-9-isopropylpurine (compound A-5) as aglycones. Principally, this study confirmed the aliphatic hydroxyl group of olomoucine-type inhibitors as a relatively suitable target for glucuronide, glucoside, xyloside, galactoside, and/or N-acetylaminoglucoside conjugation. Of the tissues examined, only the mouse micro Mezidruhové rozdíly v glykosidaci v savčích tkáních ukazují na nejednoznačnosti při extrapolaci endobiotických a xenobiotických cest ze zvířat na člověka. Interspecies differences in glycosidation potential in mammalian tissues represent a factor contributing to ambiguity when endobiotic and/or xenobiotic metabolic pathways are extrapolated from animals to man. Using the TLC/autoradiographic technique, we conducted an in vitro investigation involving mouse, rat, monkey, as well as human liver and kidney microsomes to evaluate their glycoconjugation potential towards (3)H-labeled, purine-derived selective inhibitors of cyclin-dependent kinases such as olomoucine, bohemine, roscovitine, 6-(2-hydroxybenzyl)amino-2-(1-hydroxymethyl-2-methylpropyl)amino-9-isopropylpurine (compound A-4), and 6-(3-hydroxybenzyl)amino-2-[(1(R/S)-hydroxymethyl)propyl]amino-9-isopropylpurine (compound A-5) as aglycones. Principally, this study confirmed the aliphatic hydroxyl group of olomoucine-type inhibitors as a relatively suitable target for glucuronide, glucoside, xyloside, galactoside, and/or N-acetylaminoglucoside conjugation. Of the tissues examined, only the mouse micro
dcterms:title
In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes Glykosidace in vitro za účelem inhibitoru cyklin dependentní kinázy olomoucinového typu a v mikrosomech hlodavců a primátů
skos:prefLabel
Glykosidace in vitro za účelem inhibitoru cyklin dependentní kinázy olomoucinového typu a v mikrosomech hlodavců a primátů In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes In vitro glycosidation potential towards Olomoucine - type cyclin-dependent kinase inhibitors in rodent and primate microsomes
skos:notation
RIV/61989592:15110/03:00007270!RIV09-MSM-15110___
n3:aktivita
n6:V n6:Z n6:P
n3:aktivity
P(GA301/02/0475), P(OC B17.20), V, Z(MSM 151100001)
n3:cisloPeriodika
4
n3:dodaniDat
n12:2009
n3:domaciTvurceVysledku
n11:5879426 n11:2769794 n11:5047633 n11:6478913 n11:5576989 n11:6974899
n3:druhVysledku
n10:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
610059
n3:idVysledku
RIV/61989592:15110/03:00007270
n3:jazykVysledku
n18:eng
n3:klicovaSlova
glycosidation; mouse; rat; monkey; human; CDK inhibitors
n3:klicoveSlovo
n4:CDK%20inhibitors n4:glycosidation n4:human n4:monkey n4:rat n4:mouse
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[C22FE7582D7E]
n3:nazevZdroje
Physiological Research (print)
n3:obor
n17:FR
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
14
n3:projekt
n7:GA301%2F02%2F0475 n7:OC%20B17.20
n3:rokUplatneniVysledku
n12:2003
n3:svazekPeriodika
52
n3:tvurceVysledku
Belejová, Marie Michnová, K. Červenková, Kateřina Michalíková, K. Šúrová, I. Hanuš, Jan Chmela, Zdeněk Brejcha, A. Veselý, Jaroslav Fuksová, Květoslava Riegrová, Dagmar Černý, B. Rypka, Miroslav Havlíček, Libor
n3:zamer
n9:MSM%20151100001
s:issn
0862-8408
s:numberOfPages
8
n15:organizacniJednotka
15110