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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F02%3A00006953%21RIV09-MSM-15110___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
Nové rozpustné deriváty hepatoprotektivního flavonolignanu silybinu (galaktosid, glukosid, laktosid a maltosid) byly studovány pro svoje vlastnosti lapačů radikálů a snižování míry lipoperoxidace. Ve shodě s výsledky cyklické volumetrie jsou glykosidy silybinu slabšími donory elektronů než aglykon, ale na modelech vychytávání radikálů (metody DPPH a TEAC) byly glykosidy lepšími lapači radikálů než samotný silybin. Glykosidy vykazovaly vyšší ochranu proti terc-butylhydroperoxidem vyvolávanou lipoperoxidaci potkaních jaterních mitochondriálních membrán, dále také lépe chránily proti toxickému účinku terc-butylhydroperoxidu na modelech potkaních erytrocytů a primárních kultur potkaních hepatocytů ve srovnání se silybinem. Glykosilace silybinu snižovala vlastní toxicitu aglykonu, pozorovanou na potkaních hepatocytech při delších intervalech inkubace. Výsledky ukazují, že glykosidy silybinu, rozpustné deriváty silybinu, jsou vhodné pro další studie a mohou mít terapeutický potenciál. New soluble derivatives of the hepatoprotective flavonolignan silybin (1), namely silybin galactoside (2), glucoside (3), lactoside (4) and maltoside (5) were investigated for their radical scavenging and antilipoperoxidation properties. According to cyclic voltammetry the results show that glycosides are weaker electron donors than silybin, although it was of interest that they were found to be more potent scavengers of the 1,1-diphenyl-2-picrylhydrazyl and the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-derived radicals. The glycosides (2)-(5) were more efficient than silybin in preventing tert-butylhydroperoxide-induced lipoperoxidation of rat liver mitochondrial membranes. Furthermore, glycosides (2)-(5) were significantly more cytoprotective than silybin in tert-butylhydroperoxide-damaged rat erythrocytes and primary hepatocyte cultures. Glycosylation of silybin substantially reduced its toxic effects in primary cultured hepatocytes observed during prolonged incubation. These res New soluble derivatives of the hepatoprotective flavonolignan silybin (1), namely silybin galactoside (2), glucoside (3), lactoside (4) and maltoside (5) were investigated for their radical scavenging and antilipoperoxidation properties. According to cyclic voltammetry the results show that glycosides are weaker electron donors than silybin, although it was of interest that they were found to be more potent scavengers of the 1,1-diphenyl-2-picrylhydrazyl and the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)-derived radicals. The glycosides (2)-(5) were more efficient than silybin in preventing tert-butylhydroperoxide-induced lipoperoxidation of rat liver mitochondrial membranes. Furthermore, glycosides (2)-(5) were significantly more cytoprotective than silybin in tert-butylhydroperoxide-damaged rat erythrocytes and primary hepatocyte cultures. Glycosylation of silybin substantially reduced its toxic effects in primary cultured hepatocytes observed during prolonged incubation. These res
dcterms:title
Antioxidační vlastnosti silybinových glykosidů Antioxidant properties of silybin glykosides Antioxidant properties of silybin glykosides
skos:prefLabel
Antioxidant properties of silybin glykosides Antioxidační vlastnosti silybinových glykosidů Antioxidant properties of silybin glykosides
skos:notation
RIV/61989592:15110/02:00006953!RIV09-MSM-15110___
n3:aktivita
n7:P n7:Z
n3:aktivity
P(GA303/98/0414), Z(MSM 151100003)
n3:cisloPeriodika
1
n3:dodaniDat
n4:2009
n3:domaciTvurceVysledku
n9:1089935 n9:8283001 n9:2514559 n9:8341362
n3:druhVysledku
n12:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
638584
n3:idVysledku
RIV/61989592:15110/02:00006953
n3:jazykVysledku
n11:eng
n3:klicovaSlova
Silybin glykosides; Radical scavenging; Lipoperoxidation; Rat hepatocytes
n3:klicoveSlovo
n15:Silybin%20glykosides n15:Rat%20hepatocytes n15:Radical%20scavenging n15:Lipoperoxidation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[0650CAD8B321]
n3:nazevZdroje
Phytotherapy Research
n3:obor
n19:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:projekt
n14:GA303%2F98%2F0414
n3:rokUplatneniVysledku
n4:2002
n3:svazekPeriodika
16
n3:tvurceVysledku
Walterová, Daniela Ulrichová, Jitka Kosina, Pavel Křen, Vladimír Grambal, František Gebhardt, Rolf
n3:zamer
n17:MSM%20151100003
s:issn
0951-418X
s:numberOfPages
7
n8:organizacniJednotka
15110