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Statements

Subject Item
n2:RIV%2F61989592%3A15110%2F01%3A00006961%21RIV09-MSM-15110___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
In vitro subcellular and cellular systems have important and irreplaceable roles in the metabolic investigations that precede the development of new potential drugs. Of these model systems, tissue slices are probably the nearest to in vivo conditions. From the experimental and complexity points of view, perfused organs lie midway between tisssue slices and whole organism. Preparation and working with liver slices is quick and easy, and, excess material can be cryopreserved and stored untill the next experiment. Slices can be prepared from a wide variety of organs and it is possible to co-incubate them. Another important feature is the possibility of interspecies comparison of slices. Different experiments can be run both in the short-term as well as long-term incubations. Each in vitro system has an important place for example, in the development of new medicaments. It is therefore important to compare and supplement experimental results from different in vitro systems when extrapolating to in In vitro subcelulární a buněčné systémy mají významné a nenahraditelné role v metabolických výzkumech, které předchází vývoji nových potenciálních léků. In vitro subcellular and cellular systems have important and irreplaceable roles in the metabolic investigations that precede the development of new potential drugs. Of these model systems, tissue slices are probably the nearest to in vivo conditions. From the experimental and complexity points of view, perfused organs lie midway between tisssue slices and whole organism. Preparation and working with liver slices is quick and easy, and, excess material can be cryopreserved and stored untill the next experiment. Slices can be prepared from a wide variety of organs and it is possible to co-incubate them. Another important feature is the possibility of interspecies comparison of slices. Different experiments can be run both in the short-term as well as long-term incubations. Each in vitro system has an important place for example, in the development of new medicaments. It is therefore important to compare and supplement experimental results from different in vitro systems when extrapolating to in
dcterms:title
Cell suspensions, cell cultures, and tissue slices - important metabolic in vitro systems Cell suspensions, cell cultures, and tissue slices - important metabolic in vitro systems Buněčné suspenze, buněčné kultury a tkáňové řezy - důležité metabolické in vitro systémy
skos:prefLabel
Buněčné suspenze, buněčné kultury a tkáňové řezy - důležité metabolické in vitro systémy Cell suspensions, cell cultures, and tissue slices - important metabolic in vitro systems Cell suspensions, cell cultures, and tissue slices - important metabolic in vitro systems
skos:notation
RIV/61989592:15110/01:00006961!RIV09-MSM-15110___
n6:aktivita
n14:P n14:Z
n6:aktivity
P(GA303/99/P002), P(OC B17.20), Z(MSM 151100001), Z(MSM 151100003)
n6:cisloPeriodika
2
n6:dodaniDat
n16:2009
n6:domaciTvurceVysledku
n10:6974899 n10:2514559 n10:5576989 n10:6478913 n10:5047633 n10:1030957
n6:druhVysledku
n12:J
n6:duvernostUdaju
n7:S
n6:entitaPredkladatele
n19:predkladatel
n6:idSjednocenehoVysledku
675025
n6:idVysledku
RIV/61989592:15110/01:00006961
n6:jazykVysledku
n17:eng
n6:klicovaSlova
In vitro systems; Tissue slices; Metabolism; Viability tests
n6:klicoveSlovo
n11:Tissue%20slices n11:In%20vitro%20systems n11:Metabolism n11:Viability%20tests
n6:kodStatuVydavatele
CZ - Česká republika
n6:kontrolniKodProRIV
[12127196C2AF]
n6:nazevZdroje
Biomedical Papers
n6:obor
n8:FR
n6:pocetDomacichTvurcuVysledku
6
n6:pocetTvurcuVysledku
8
n6:projekt
n15:GA303%2F99%2FP002 n15:OC%20B17.20
n6:rokUplatneniVysledku
n16:2001
n6:svazekPeriodika
145
n6:tvurceVysledku
Rypka, Miroslav Ulrichová, Jitka Veselý, Jaroslav Maurel, Patrick Belejová, Marie Modrianský, Martin Chmela, Zdeněk Červenková, Kateřina
n6:zamer
n18:MSM%20151100003 n18:MSM%20151100001
s:issn
0862-481X
s:numberOfPages
4
n4:organizacniJednotka
15110