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Statements

Subject Item
n2:RIV%2F61989100%3A27650%2F13%3A86087158%21RIV14-MSM-27650___
rdf:type
skos:Concept n5:Vysledek
rdfs:seeAlso
http://iopscience.iop.org/1742-6596/429/1/012032
dcterms:description
The aim of this pilot study was to evaluate perspectives of the assessment of non-specific biological effects of airborne particulate matter including nanoparticles using appropriate immunological assays. We have selected various in vitro immunological assays to establish an array allowing us to monitor activation of the cell-mediated and humoral response of both the innate and adaptive immunity. To assess comprehensive interactions and effects, the assays were performed in whole blood cultures from healthy volunteers and we used an original airborne particle mixture from high pollution period in Ostrava region representing areas with one of the most polluted air in Europe. Even if certain effects were observed, the results of the immunological assays did not prove significant effects of airborne particles on immune cells’ functions of healthy persons. However, obtained data do not exclude health risks of long-term exposure to airborne particles, especially in case of individuals with genetic predisposition to certain diseases or already existing disease. This study emphasizes the in vitro assessment of complex effects of airborne particles in conditions similar to actual ones in an organism exposed to particle mixture present in the polluted air. The aim of this pilot study was to evaluate perspectives of the assessment of non-specific biological effects of airborne particulate matter including nanoparticles using appropriate immunological assays. We have selected various in vitro immunological assays to establish an array allowing us to monitor activation of the cell-mediated and humoral response of both the innate and adaptive immunity. To assess comprehensive interactions and effects, the assays were performed in whole blood cultures from healthy volunteers and we used an original airborne particle mixture from high pollution period in Ostrava region representing areas with one of the most polluted air in Europe. Even if certain effects were observed, the results of the immunological assays did not prove significant effects of airborne particles on immune cells’ functions of healthy persons. However, obtained data do not exclude health risks of long-term exposure to airborne particles, especially in case of individuals with genetic predisposition to certain diseases or already existing disease. This study emphasizes the in vitro assessment of complex effects of airborne particles in conditions similar to actual ones in an organism exposed to particle mixture present in the polluted air.
dcterms:title
Immunological Assays as an Opportunity of Assessment of Health Risks of Airborne Particle Mixture Including Nanoparticles Immunological Assays as an Opportunity of Assessment of Health Risks of Airborne Particle Mixture Including Nanoparticles
skos:prefLabel
Immunological Assays as an Opportunity of Assessment of Health Risks of Airborne Particle Mixture Including Nanoparticles Immunological Assays as an Opportunity of Assessment of Health Risks of Airborne Particle Mixture Including Nanoparticles
skos:notation
RIV/61989100:27650/13:86087158!RIV14-MSM-27650___
n5:predkladatel
n13:orjk%3A27650
n3:aktivita
n14:P
n3:aktivity
P(ED0036/01/01)
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n10:3248313 n10:6308422
n3:druhVysledku
n18:D
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
78911
n3:idVysledku
RIV/61989100:27650/13:86087158
n3:jazykVysledku
n21:eng
n3:klicovaSlova
lymphocyte proliferation; cytokines; respiratory burst; phagocytosis; allergy; PM2,5, immunomodulatory effects
n3:klicoveSlovo
n8:allergy n8:respiratory%20burst n8:5 n8:phagocytosis n8:cytokines n8:PM2 n8:lymphocyte%20proliferation n8:immunomodulatory%20effects
n3:kontrolniKodProRIV
[EB592C0D8C58]
n3:mistoKonaniAkce
Grenoble
n3:mistoVydani
[Francie]
n3:nazevZdroje
International Conference on Safe Production and Use of Nanomaterials : book of abstracts : Minatec, Grenoble, France, 13-15 November 2012
n3:obor
n23:DI
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n6:ED0036%2F01%2F01
n3:rokUplatneniVysledku
n15:2013
n3:tvurceVysledku
Lach, Karel Lochman, Ivo Lochmanová, Alexandra Danihelka, Pavel Mička, Vladimír Brzicová, Táňa
n3:typAkce
n19:WRD
n3:zahajeniAkce
2012-11-13+01:00
s:issn
1742-6588
s:numberOfPages
10
n22:doi
10.1088/1742-6596/429/1/012032
n17:hasPublisher
Neuveden
n11:organizacniJednotka
27650