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Statements

Subject Item
n2:RIV%2F61988987%3A17310%2F12%3AA13017G5%21RIV13-MSM-17310___
rdf:type
skos:Concept n10:Vysledek
dcterms:description
The aim was to detect antimutagenic and DNA protective effects of a plant extract from bark of Magnolia officinalis adversing oxidative DNA damage. The ability to inhibit mutagenicity induced by tert-butyl hydroperoxide (t-BOOH) and hydrogen peroxide (H2O2) was determined with Ames test using Salmonella typhimurium His- TA102 bacterial strain. Inhibition values of 72.8 and 98.7 % were detected for t-BOOH and H2O2, respectively. The protective effect of the extract against DNA strand scission induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in the plasmid DNA proved a significant inhibition of DNA damage. The aim was to detect antimutagenic and DNA protective effects of a plant extract from bark of Magnolia officinalis adversing oxidative DNA damage. The ability to inhibit mutagenicity induced by tert-butyl hydroperoxide (t-BOOH) and hydrogen peroxide (H2O2) was determined with Ames test using Salmonella typhimurium His- TA102 bacterial strain. Inhibition values of 72.8 and 98.7 % were detected for t-BOOH and H2O2, respectively. The protective effect of the extract against DNA strand scission induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in the plasmid DNA proved a significant inhibition of DNA damage.
dcterms:title
Antigenotoxic effects of a bark extract from Magnolia officinalis Antigenotoxic effects of a bark extract from Magnolia officinalis
skos:prefLabel
Antigenotoxic effects of a bark extract from Magnolia officinalis Antigenotoxic effects of a bark extract from Magnolia officinalis
skos:notation
RIV/61988987:17310/12:A13017G5!RIV13-MSM-17310___
n10:predkladatel
n11:orjk%3A17310
n4:aktivita
n7:P
n4:aktivity
P(ED2.1.00/03.0100)
n4:cisloPeriodika
1
n4:dodaniDat
n12:2013
n4:domaciTvurceVysledku
n14:2358514 n14:9018247
n4:druhVysledku
n8:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
122948
n4:idVysledku
RIV/61988987:17310/12:A13017G5
n4:jazykVysledku
n19:eng
n4:klicovaSlova
Ames test; Antimutagenicity; DNA strand scission; Magnolia officinalis
n4:klicoveSlovo
n5:Antimutagenicity n5:DNA%20strand%20scission n5:Magnolia%20officinalis n5:Ames%20test
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[418926B1DD52]
n4:nazevZdroje
Časopis slezského zemského muzea (A)
n4:obor
n16:EE
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
2
n4:projekt
n15:ED2.1.00%2F03.0100
n4:rokUplatneniVysledku
n12:2012
n4:svazekPeriodika
3
n4:tvurceVysledku
Rybková, Zuzana Malachová, Kateřina
s:issn
1211-3026
s:numberOfPages
6
n9:organizacniJednotka
17310