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Statements

Subject Item
n2:RIV%2F61988987%3A17110%2F13%3AA14019WF%21RIV14-MSM-17110___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
A combination of antiarrhythmic drugs with ?1 selective blocking agents has often been used. Both these types of drugs are metabolized via the cytochrome P450 (CYP) enzyme system, and therefore potential drug interactions are of considerable clinical significance. The antiarrhythmic agent propafenone undergoes CYP 2D6-dependent metabolism. Propafenone is also an inhibitor of the enzyme; the inhibitory constant has been estimated at 50 nmol/L, similar to that of quinidine (60 nmol/L). Metoprolol, a ?1 selective blocking agent, undergoes extensive presystemic elimination by CYP 2D6, and it has been shown that metabolites do not substantially contribute to the ?1-blockade. A combination of antiarrhythmic drugs with ?1 selective blocking agents has often been used. Both these types of drugs are metabolized via the cytochrome P450 (CYP) enzyme system, and therefore potential drug interactions are of considerable clinical significance. The antiarrhythmic agent propafenone undergoes CYP 2D6-dependent metabolism. Propafenone is also an inhibitor of the enzyme; the inhibitory constant has been estimated at 50 nmol/L, similar to that of quinidine (60 nmol/L). Metoprolol, a ?1 selective blocking agent, undergoes extensive presystemic elimination by CYP 2D6, and it has been shown that metabolites do not substantially contribute to the ?1-blockade.
dcterms:title
Clinically important interaction between metoprolol and propafenone Clinically important interaction between metoprolol and propafenone
skos:prefLabel
Clinically important interaction between metoprolol and propafenone Clinically important interaction between metoprolol and propafenone
skos:notation
RIV/61988987:17110/13:A14019WF!RIV14-MSM-17110___
n3:predkladatel
n4:orjk%3A17110
n5:aktivita
n7:V n7:I
n5:aktivity
I, V
n5:cisloPeriodika
4
n5:dodaniDat
n10:2014
n5:domaciTvurceVysledku
n13:9790365
n5:druhVysledku
n16:J
n5:duvernostUdaju
n11:S
n5:entitaPredkladatele
n6:predkladatel
n5:idSjednocenehoVysledku
65709
n5:idVysledku
RIV/61988987:17110/13:A14019WF
n5:jazykVysledku
n15:eng
n5:klicovaSlova
Aged; Anti-Arrhythmia Agents; Antihypertensive Agents; Atrial Fibrillation; Cytochrome P-450 CYP2D6; Diuretics; Drug Interactions; Dyspnea; Fatigue; Hypertension; Medication; Reconciliation; Metoprolol; Propafenone
n5:klicoveSlovo
n8:Aged n8:Fatigue n8:Reconciliation n8:Anti-Arrhythmia%20Agents n8:Atrial%20Fibrillation n8:Drug%20Interactions n8:Hypertension n8:Diuretics n8:Metoprolol n8:Medication n8:Dyspnea n8:Cytochrome%20P-450%20CYP2D6 n8:Antihypertensive%20Agents n8:Propafenone
n5:kodStatuVydavatele
CA - Kanada
n5:kontrolniKodProRIV
[A764AC9F15BD]
n5:nazevZdroje
CAN FAM PHYSICIAN
n5:obor
n17:FR
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
5
n5:rokUplatneniVysledku
n10:2013
n5:svazekPeriodika
59
n5:tvurceVysledku
Grundmann, Milan Perinova, Ilona Duricova, Jana Kacirova, Ivana Jurckova, Nikola
n5:wos
000317812300014
s:issn
0008-350X
s:numberOfPages
3
n14:organizacniJednotka
17110