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Statements

Subject Item
n2:RIV%2F61988987%3A17110%2F10%3AA110109A%21RIV11-MSM-17110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Metoprolol/alfa-hydroxymetoprolol metabolic ratio (MR) 3 hours after a single metoprolol dose is used for cytochrome P450 2D6 phenotyping. The aim was to compare cytochrome P450 2D6 metabolic activity after the first metoprolol dose and in steady state. Thirteen adult hypertinsive patients (7 females) in whom an antroduction of the beta-blocker metoprolol was indicated were included. Age (mean ? SD) was 42,8 ? 12,9 years, weight (mean ? SD) was 94,0 ? 25,4 kg. Metoprolol dose was chosen based on clinical grounds on the day of metoprolol first ingestion. Blood samples were drawn after the first dose and at least 2 weeks since metoprolol introduction to ensure steady state. The patients were phenotyped as extensive metabolizers in both periods, after metoprolol first ingestion and in steady state. We observed a significant correlation (rs = 0,8418, P = 0,0003) between the metoprolol/alfa-hydroxymetoprolol MRs. Metoprolol/alfa-hydroxymetoprolol metabolic ratio (MR) 3 hours after a single metoprolol dose is used for cytochrome P450 2D6 phenotyping. The aim was to compare cytochrome P450 2D6 metabolic activity after the first metoprolol dose and in steady state. Thirteen adult hypertinsive patients (7 females) in whom an antroduction of the beta-blocker metoprolol was indicated were included. Age (mean ? SD) was 42,8 ? 12,9 years, weight (mean ? SD) was 94,0 ? 25,4 kg. Metoprolol dose was chosen based on clinical grounds on the day of metoprolol first ingestion. Blood samples were drawn after the first dose and at least 2 weeks since metoprolol introduction to ensure steady state. The patients were phenotyped as extensive metabolizers in both periods, after metoprolol first ingestion and in steady state. We observed a significant correlation (rs = 0,8418, P = 0,0003) between the metoprolol/alfa-hydroxymetoprolol MRs.
dcterms:title
Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state
skos:prefLabel
Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state
skos:notation
RIV/61988987:17110/10:A110109A!RIV11-MSM-17110___
n3:aktivita
n11:S
n3:aktivity
S
n3:cisloPeriodika
59
n3:dodaniDat
n15:2011
n3:domaciTvurceVysledku
n10:7160909 n10:9790365
n3:druhVysledku
n12:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
251479
n3:idVysledku
RIV/61988987:17110/10:A110109A
n3:jazykVysledku
n17:eng
n3:klicovaSlova
cytochrome P450 2D6 - phenotype; probe drug; metoprolol
n3:klicoveSlovo
n8:cytochrome%20P450%202D6 n8:probe%20drug n8:metoprolol
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[39AAF2E99B18]
n3:nazevZdroje
česká a slovenská farmacie
n3:obor
n4:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n15:2010
n3:svazekPeriodika
5
n3:tvurceVysledku
Ďuricová, J. Peřinová, Ilona Kacířová, Ivana Grundmann, Milan
s:issn
1210-7816
s:numberOfPages
5
n5:organizacniJednotka
17110