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Statements

Subject Item
n2:RIV%2F61988987%3A17110%2F03%3AA1000VRL%21RIV10-MSM-17110___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The aim of this study was a contemporaneous measurement and a mutual comparison of plasma cells proliferative activity and grade of apoptosis in patients with monoclonal gammopathy of undetermined significance (MGUS) and various phases of MM i.e. smoldering (SMM), stable/plateau and active (progression/relapse) forms of this disease. The analyzed group of 197 patients consisted of 30 MGUS, 21 SMM, 82 patients examined at the time of MM diagnosis and 64 patients analyzed during various phases of the disease after previous chemotherapy. Plasma cell proliferative activity was measured by means of a propidium iodide index (PC-PI) examined by flow cytometry using a DNA/CD138 double staining technique. For detection of plasma cells entering apoptosis (PC-AI) flow cytometry method with annexin. V FITC and MoAb CD138 was used. The aim of this study was a contemporaneous measurement and a mutual comparison of plasma cells proliferative activity and grade of apoptosis in patients with monoclonal gammopathy of undetermined significance (MGUS) and various phases of MM i.e. smoldering (SMM), stable/plateau and active (progression/relapse) forms of this disease. The analyzed group of 197 patients consisted of 30 MGUS, 21 SMM, 82 patients examined at the time of MM diagnosis and 64 patients analyzed during various phases of the disease after previous chemotherapy. Plasma cell proliferative activity was measured by means of a propidium iodide index (PC-PI) examined by flow cytometry using a DNA/CD138 double staining technique. For detection of plasma cells entering apoptosis (PC-AI) flow cytometry method with annexin. V FITC and MoAb CD138 was used.
dcterms:title
A contribution to examination of propidium iodide and annexin V plasma cells indices in multiple myeloma A contribution to examination of propidium iodide and annexin V plasma cells indices in multiple myeloma
skos:prefLabel
A contribution to examination of propidium iodide and annexin V plasma cells indices in multiple myeloma A contribution to examination of propidium iodide and annexin V plasma cells indices in multiple myeloma
skos:notation
RIV/61988987:17110/03:A1000VRL!RIV10-MSM-17110___
n3:aktivita
n16:S
n3:aktivity
S
n3:cisloPeriodika
5
n3:dodaniDat
n6:2010
n3:domaciTvurceVysledku
n17:3867781
n3:druhVysledku
n15:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
596844
n3:idVysledku
RIV/61988987:17110/03:A1000VRL
n3:jazykVysledku
n7:eng
n3:klicovaSlova
multiple myeloma; plasma cell; propidium iodide index; annexin V index; proliferation; apoptosis
n3:klicoveSlovo
n10:plasma%20cell n10:multiple%20myeloma n10:apoptosis n10:annexin%20V%20index n10:proliferation n10:propidium%20iodide%20index
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[1B0A8E3F7015]
n3:nazevZdroje
NEOPLASMA
n3:obor
n4:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:rokUplatneniVysledku
n6:2003
n3:svazekPeriodika
50
n3:tvurceVysledku
Martínek, Arnošt
n3:wos
000186334800009
s:issn
0028-2685
s:numberOfPages
9
n5:organizacniJednotka
17110