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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F13%3A00441336%21RIV15-AV0-61389030
rdf:type
skos:Concept n20:Vysledek
dcterms:description
Brassinosteroids are endogenous plant polyhydroxysteroids that are essential for normal plant growth and development. They induce cell elongation and division, increase DNA and RNA polymerase activity, interact synergistically with auxins, stimulate ethylene production, and increase tolerance to temperature, water, and salinity stress. They are observed in many plant species and are present in nearly every part of the plant, although the highest concentrations occur in the reproductive organs. In mammalian cells, brassinosteroids inhibit cell growth and affect cell cycle progression; as such, they have potential for development as anticancer agents. Moreover, brassinosteroids and their synthetic derivatives possess antiangiogenic properties that could be effective in the treatment of any carcinoma. As such, they are an interesting source of lead compounds for developing novel natural product-derived anticancer drugs, and their properties have attracted the attention of many specialists in the fields of chemistry, biochemistry, pharmacology, plant physiology, and agriculture. Brassinosteroids are endogenous plant polyhydroxysteroids that are essential for normal plant growth and development. They induce cell elongation and division, increase DNA and RNA polymerase activity, interact synergistically with auxins, stimulate ethylene production, and increase tolerance to temperature, water, and salinity stress. They are observed in many plant species and are present in nearly every part of the plant, although the highest concentrations occur in the reproductive organs. In mammalian cells, brassinosteroids inhibit cell growth and affect cell cycle progression; as such, they have potential for development as anticancer agents. Moreover, brassinosteroids and their synthetic derivatives possess antiangiogenic properties that could be effective in the treatment of any carcinoma. As such, they are an interesting source of lead compounds for developing novel natural product-derived anticancer drugs, and their properties have attracted the attention of many specialists in the fields of chemistry, biochemistry, pharmacology, plant physiology, and agriculture.
dcterms:title
Brassinosteroids and their Biological Activities Brassinosteroids and their Biological Activities
skos:prefLabel
Brassinosteroids and their Biological Activities Brassinosteroids and their Biological Activities
skos:notation
RIV/61389030:_____/13:00441336!RIV15-AV0-61389030
n3:aktivita
n10:P n10:I
n3:aktivity
I, P(ED0007/01/01), P(IAA400550801)
n3:dodaniDat
n4:2015
n3:domaciTvurceVysledku
n9:6978932 n9:4712048 n9:4952340
n3:druhVysledku
n14:C
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
63825
n3:idVysledku
RIV/61389030:_____/13:00441336
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Anticancer activity; apoptosis; bioassay
n3:klicoveSlovo
n7:apoptosis n7:Anticancer%20activity n7:bioassay
n3:kontrolniKodProRIV
[5493CCBED8F1]
n3:mistoVydani
Heidelberg
n3:nazevZdroje
Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetStranKnihy
4242
n3:pocetTvurcuVysledku
3
n3:projekt
n8:ED0007%2F01%2F01 n8:IAA400550801
n3:rokUplatneniVysledku
n4:2013
n3:tvurceVysledku
Rárová, Lucie Oklešťková, Jana Strnad, Miroslav
s:numberOfPages
21
n19:doi
10.1007/978-3-642-22144-6_174
n16:hasPublisher
Springer-Verlag
n12:isbn
978-3-642-22143-9