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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F13%3A00423094%21RIV14-GA0-61389030
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Variously substituted 2-hydroxy-N-(arylallcyl)benzamides were prepared and screened for anti-proliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent compounds N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (6k) reduced proliferation and induced apoptosis in the melanoma cell line G361 in a dose-dependent manner, as shown by decrease in 5-bromo-2'-deoxyuridine incorporation and increase in several apoptotic markers, including subdiploid population increase, activation of caspases and site-specific poly-(ADP-ribose)polymerase (PARP) cleavage. Variously substituted 2-hydroxy-N-(arylallcyl)benzamides were prepared and screened for anti-proliferative and cytotoxic activity in cancer cell lines in vitro. Five compounds, out of 33 showed single-digit micromolar IC50 values against several human cancer cell lines. One of the most potent compounds N-((R)-1-(4-chlorophenylcarbamoyl)-2-phenylethyl)-5-chloro-2-hydroxybenzamide (6k) reduced proliferation and induced apoptosis in the melanoma cell line G361 in a dose-dependent manner, as shown by decrease in 5-bromo-2'-deoxyuridine incorporation and increase in several apoptotic markers, including subdiploid population increase, activation of caspases and site-specific poly-(ADP-ribose)polymerase (PARP) cleavage.
dcterms:title
Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines
skos:prefLabel
Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines
skos:notation
RIV/61389030:_____/13:00423094!RIV14-GA0-61389030
n13:predkladatel
n14:ico%3A61389030
n3:aktivita
n4:P n4:Z n4:S
n3:aktivity
P(ED2.1.00/03.0101), P(GA301/08/1649), P(GAP305/12/0783), S, Z(AV0Z50380511)
n3:cisloPeriodika
2013
n3:dodaniDat
n10:2014
n3:domaciTvurceVysledku
n17:2404338 n17:9961216 n17:1793411
n3:druhVysledku
n20:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
108907
n3:idVysledku
RIV/61389030:_____/13:00423094
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Diamides; Apoptosis; Cytotoxicity
n3:klicoveSlovo
n16:Diamides n16:Cytotoxicity n16:Apoptosis
n3:kodStatuVydavatele
FR - Francouzská republika
n3:kontrolniKodProRIV
[477C1D723230]
n3:nazevZdroje
European Journal of Medicinal Chemistry
n3:obor
n15:CE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
7
n3:projekt
n8:ED2.1.00%2F03.0101 n8:GA301%2F08%2F1649 n8:GAP305%2F12%2F0783
n3:rokUplatneniVysledku
n10:2013
n3:svazekPeriodika
68
n3:tvurceVysledku
Kryštof, Vladimír Pauk, K. Hanousek, J. Řezníčková, Eva Jorda, Radek Imramovský, A. Dušek, J.
n3:wos
000326902300027
n3:zamer
n18:AV0Z50380511
s:issn
0223-5234
s:numberOfPages
7
n5:doi
10.1016/j.ejmech.2013.08.009