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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F12%3A00380748%21RIV13-AV0-61389030
rdf:type
skos:Concept n6:Vysledek
rdfs:seeAlso
http://home.ueb.cas.cz/publikace/2012_Haq_ACTA_POLONIAE_PHARMACEUTICA_707.pdf
dcterms:description
Inflammation is the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body. This study was aimed to evaluate the anti-inflammatory and platelet aggregation effects of three medicinal plants of Pakistan. Methanolic extract of Garden pea inhibited arachidonic acid (AA)-induced platelet aggregation (IC50 = 35 μg/mL) and platelet activating factor (PAF)-induced platelet aggregation (IC50 = 38 μg/mL) in a dose dependent fashion. Methanolic extract of Desi chickpea inhibited arachidonic acid (AA) induced platelet aggregation (IC50 value = AA = 46 μg/mL) in dose dependent fashion while was found not active against PAF-induced platelet aggregation. Methanolic extract of Kabuli chickpea was found not active against both arachidonic acid (AA)-induced platelet aggregation and PAF-induced platelet aggregation. The best potential to inhibit in vitro COX-2 activity showed garden pea (Pisum sativum; the synthesis of PGE2 reduced by 92% in comparison with untreated control wells) followed by Desi chickpea (Cicer arietinum var; 87% inhibition) and Kabuli chickpea extracts (Cicer arietinum var; 65% inhibition). All extracts were tested at concentration 20 μg/mL. in COX-2 assay.The results indicate that if the same were happening in vivo, Garden pea, Desi chickpea and Kabuli chickpea could be useful as natural antithrombotic anti-inflammatory materials. Inflammation is the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body. This study was aimed to evaluate the anti-inflammatory and platelet aggregation effects of three medicinal plants of Pakistan. Methanolic extract of Garden pea inhibited arachidonic acid (AA)-induced platelet aggregation (IC50 = 35 μg/mL) and platelet activating factor (PAF)-induced platelet aggregation (IC50 = 38 μg/mL) in a dose dependent fashion. Methanolic extract of Desi chickpea inhibited arachidonic acid (AA) induced platelet aggregation (IC50 value = AA = 46 μg/mL) in dose dependent fashion while was found not active against PAF-induced platelet aggregation. Methanolic extract of Kabuli chickpea was found not active against both arachidonic acid (AA)-induced platelet aggregation and PAF-induced platelet aggregation. The best potential to inhibit in vitro COX-2 activity showed garden pea (Pisum sativum; the synthesis of PGE2 reduced by 92% in comparison with untreated control wells) followed by Desi chickpea (Cicer arietinum var; 87% inhibition) and Kabuli chickpea extracts (Cicer arietinum var; 65% inhibition). All extracts were tested at concentration 20 μg/mL. in COX-2 assay.The results indicate that if the same were happening in vivo, Garden pea, Desi chickpea and Kabuli chickpea could be useful as natural antithrombotic anti-inflammatory materials.
dcterms:title
PLATELET AGGREGATION AND ANTI-INFLAMMATORY EFFECTS OF GARDEN PEA, DESI CHICKPEA AND KABULI CHICKPEA PLATELET AGGREGATION AND ANTI-INFLAMMATORY EFFECTS OF GARDEN PEA, DESI CHICKPEA AND KABULI CHICKPEA
skos:prefLabel
PLATELET AGGREGATION AND ANTI-INFLAMMATORY EFFECTS OF GARDEN PEA, DESI CHICKPEA AND KABULI CHICKPEA PLATELET AGGREGATION AND ANTI-INFLAMMATORY EFFECTS OF GARDEN PEA, DESI CHICKPEA AND KABULI CHICKPEA
skos:notation
RIV/61389030:_____/12:00380748!RIV13-AV0-61389030
n6:predkladatel
n7:ico%3A61389030
n3:aktivita
n16:Z n16:S
n3:aktivity
S, Z(AV0Z50380511)
n3:cisloPeriodika
4
n3:dodaniDat
n19:2013
n3:domaciTvurceVysledku
n11:2500760 n11:8215359
n3:druhVysledku
n18:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
158895
n3:idVysledku
RIV/61389030:_____/12:00380748
n3:jazykVysledku
n5:eng
n3:klicovaSlova
platelet aggregation; Garden pea; Desi chickpea
n3:klicoveSlovo
n9:platelet%20aggregation n9:Garden%20pea n9:Desi%20chickpea
n3:kodStatuVydavatele
PL - Polská republika
n3:kontrolniKodProRIV
[4EBF29C01C9F]
n3:nazevZdroje
Acta Poloniae Pharmaceutica: drug research
n3:obor
n13:EF
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n19:2012
n3:svazekPeriodika
69
n3:tvurceVysledku
ALI KHAN, B. AHMED, S. ZIA-UL-HAQ, M. Ahmad, S. Kutil, Zsófia Landa, Přemysl QAYUM, M.
n3:wos
000307689100018
n3:zamer
n4:AV0Z50380511
s:issn
0001-6837
s:numberOfPages
5