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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F11%3A00368598%21RIV12-AV0-61389030
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16 beta,17 alpha,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation. Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16 beta,17 alpha,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation.
dcterms:title
Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1 Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1
skos:prefLabel
Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1 Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1
skos:notation
RIV/61389030:_____/11:00368598!RIV12-AV0-61389030
n12:predkladatel
n13:ico%3A61389030
n3:aktivita
n10:Z n10:P
n3:aktivity
P(ED0007/01/01), P(GA301/08/1649), Z(AV0Z50380511), Z(MSM6198959216)
n3:cisloPeriodika
9
n3:dodaniDat
n14:2012
n3:domaciTvurceVysledku
n19:4952340 n19:4712048 n19:6978932
n3:druhVysledku
n4:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
233852
n3:idVysledku
RIV/61389030:_____/11:00368598
n3:jazykVysledku
n18:eng
n3:klicovaSlova
POTENT ANTITUMOR SAPONIN; CHOLESTANE GLYCOSIDES; ORNITHOGALUM-SAUNDERSIAE; SIDE-CHAINS; AGLYCONE
n3:klicoveSlovo
n11:SIDE-CHAINS n11:AGLYCONE n11:CHOLESTANE%20GLYCOSIDES n11:ORNITHOGALUM-SAUNDERSIAE n11:POTENT%20ANTITUMOR%20SAPONIN
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[CBD2C97632B2]
n3:nazevZdroje
Journal of Medicinal Chemistry
n3:obor
n9:EF
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n16:ED0007%2F01%2F01 n16:GA301%2F08%2F1649
n3:rokUplatneniVysledku
n14:2011
n3:svazekPeriodika
54
n3:tvurceVysledku
Wojtkielewicz, A. Strnad, Miroslav Morzycki, J. W. Oklešťková, Jana Rárová, Lucie Maj, J.
n3:wos
000290126800014
n3:zamer
n6:AV0Z50380511 n6:MSM6198959216
s:issn
0022-2623
s:numberOfPages
8
n20:doi
10.1021/jm101648h