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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F11%3A00368591%21RIV12-AV0-61389030
rdf:type
skos:Concept n13:Vysledek
dcterms:description
The three-step synthesis of 4-benzyl-1H-pyrazole-3,5-diamines 2 from commercially available aldehydes 3 is given. The Knoevenagel condensation was utilized to assemble the initial carbon framework, resulting in the benzylidenemalononitriles 4 which were directly transformed by the reduction of the electron deficient C=C bond to benzylmalononitriles 5. Subsequent cycloaddition of hydrazine with 5 afforded the desired pyrazoles 2. Due to the high similarity with 4-arylazo-1H-pyrazole-3,5-diamines, the biological activities of the 4-benzyl-1H-pyrazole-3,5-diamines 2 were evaluated while focusing on the inhibition of cyclin-dependent kinases (CDKs), but no significant results were obtained. The three-step synthesis of 4-benzyl-1H-pyrazole-3,5-diamines 2 from commercially available aldehydes 3 is given. The Knoevenagel condensation was utilized to assemble the initial carbon framework, resulting in the benzylidenemalononitriles 4 which were directly transformed by the reduction of the electron deficient C=C bond to benzylmalononitriles 5. Subsequent cycloaddition of hydrazine with 5 afforded the desired pyrazoles 2. Due to the high similarity with 4-arylazo-1H-pyrazole-3,5-diamines, the biological activities of the 4-benzyl-1H-pyrazole-3,5-diamines 2 were evaluated while focusing on the inhibition of cyclin-dependent kinases (CDKs), but no significant results were obtained.
dcterms:title
THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE
skos:prefLabel
THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE THE SYNTHESIS OF SOME DERIVATIVES BASED ON THE 4-BENZYL-1H-PYRAZOLE-3,5-DIAMINE CORE
skos:notation
RIV/61389030:_____/11:00368591!RIV12-AV0-61389030
n13:predkladatel
n14:ico%3A61389030
n4:aktivita
n9:Z n9:P
n4:aktivity
P(GA204/08/0511), P(GA301/08/1649), Z(AV0Z50380511), Z(MSM6198959216)
n4:cisloPeriodika
2
n4:dodaniDat
n15:2012
n4:domaciTvurceVysledku
n7:9961216 Cankař, Petr
n4:druhVysledku
n20:J
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
233917
n4:idVysledku
RIV/61389030:_____/11:00368591
n4:jazykVysledku
n17:eng
n4:klicovaSlova
Knoevenagel Condensation; Olefin Reduction; CDK; Hydrazine Cycloaddition; Pyrazole-3,5-diamine
n4:klicoveSlovo
n6:CDK n6:Hydrazine%20Cycloaddition n6:Pyrazole-3 n6:Olefin%20Reduction n6:5-diamine n6:Knoevenagel%20Condensation
n4:kodStatuVydavatele
JP - Japonsko
n4:kontrolniKodProRIV
[A4C101C34E46]
n4:nazevZdroje
Heterocycles
n4:obor
n18:CE
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
3
n4:projekt
n19:GA301%2F08%2F1649 n19:GA204%2F08%2F0511
n4:rokUplatneniVysledku
n15:2011
n4:svazekPeriodika
88
n4:tvurceVysledku
Cankař, Petr Jedinák, L. Kryštof, Vladimír
n4:wos
000287562900012
n4:zamer
n5:AV0Z50380511 n5:MSM6198959216
s:issn
0385-5414
s:numberOfPages
13
n11:doi
10.3987/COM-10-12101