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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F11%3A00365270%21RIV12-AV0-61389030
rdf:type
n16:Vysledek skos:Concept
dcterms:description
DNA double-strand breaks (DSBs) pose one of the most severe threats to genome integrity, potentially leading to cell death. After detection of a DSB, the DNA damage and repair response is initiated and the DSB is repaired by non-homologous end joining and/or homologous recombination. Many components of these processes are still unknown in Arabidopsis thaliana. In this work, we characterized gamma-irradiation and mitomycin C induced 1 (GMI1), a member of the SMC-hinge domain-containing protein family. RT-PCR analysis and promoter-GUS fusion studies showed that gamma-irradiation, the radio-mimetic drug bleocin, and the DNA cross-linking agent mitomycin C strongly enhance GMI1 expression particularly in meristematic tissues. The induction of GMI1 by gamma-irradiation depends on the signalling kinase Ataxia telangiectasia-mutated (ATM) but not on ATM and Rad3-related (ATR). DNA double-strand breaks (DSBs) pose one of the most severe threats to genome integrity, potentially leading to cell death. After detection of a DSB, the DNA damage and repair response is initiated and the DSB is repaired by non-homologous end joining and/or homologous recombination. Many components of these processes are still unknown in Arabidopsis thaliana. In this work, we characterized gamma-irradiation and mitomycin C induced 1 (GMI1), a member of the SMC-hinge domain-containing protein family. RT-PCR analysis and promoter-GUS fusion studies showed that gamma-irradiation, the radio-mimetic drug bleocin, and the DNA cross-linking agent mitomycin C strongly enhance GMI1 expression particularly in meristematic tissues. The induction of GMI1 by gamma-irradiation depends on the signalling kinase Ataxia telangiectasia-mutated (ATM) but not on ATM and Rad3-related (ATR).
dcterms:title
GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis
skos:prefLabel
GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis
skos:notation
RIV/61389030:_____/11:00365270!RIV12-AV0-61389030
n16:predkladatel
n18:ico%3A61389030
n3:aktivita
n8:P n8:Z
n3:aktivity
P(1M0505), P(LC06004), Z(AV0Z50380511)
n3:cisloPeriodika
3
n3:dodaniDat
n20:2012
n3:domaciTvurceVysledku
n14:3566544 n14:1955241
n3:druhVysledku
n6:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
201394
n3:idVysledku
RIV/61389030:_____/11:00365270
n3:jazykVysledku
n4:eng
n3:klicovaSlova
structural maintenance of chromosomes; DNA repair; somatic homologous recombination
n3:klicoveSlovo
n12:DNA%20repair n12:structural%20maintenance%20of%20chromosomes n12:somatic%20homologous%20recombination
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[DC12F880D188]
n3:nazevZdroje
Plant Journal
n3:obor
n5:EI
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
9
n3:projekt
n7:1M0505 n7:LC06004
n3:rokUplatneniVysledku
n20:2011
n3:svazekPeriodika
67
n3:tvurceVysledku
Schweizer, D. Nizhynska, V. Kozák, Jaroslav Angelis, Karel Bohmdorfer, G. Kreil, D. P. Brunmeir, R. Schleiffer, A. Ferscha, S.
n3:wos
000293176600004
n3:zamer
n13:AV0Z50380511
s:issn
0960-7412
s:numberOfPages
14
n17:doi
10.1111/j.1365-313X.2011.04604.x