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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F10%3A00357894%21RIV11-GA0-61389030
rdf:type
n6:Vysledek skos:Concept
dcterms:description
A number of compounds have been reported to be specific inhibitors of protein kinases mediated by structural-based selectivity,but the development of specific inhibitors has not yet been addressed in plant science.Here we tested C2,C6,and N9-trisubstituted purines to determine the basic relationship between their chemical structure and inhibitory activity versus a plant mitogen-activated protein kinase (MAPK).Modification of substitution at positions C2 and N9 caused increased inhibitory activity of 6-benzylaminopurine analogs.In the case of 6-isopentenyladenine derivatives, the addition of a methyl group at position N9 caused at least 2-fold increased inhibitory activity, as compared with the addition of an isopropyl group. The data indicate that the selectivity and potency of inhibitors can be improved by modification of the chemical structure, suggesting that trisubstituted purines are powerful tools for probing biological processes and understanding the physiological roles of MAPK signaling. A number of compounds have been reported to be specific inhibitors of protein kinases mediated by structural-based selectivity,but the development of specific inhibitors has not yet been addressed in plant science.Here we tested C2,C6,and N9-trisubstituted purines to determine the basic relationship between their chemical structure and inhibitory activity versus a plant mitogen-activated protein kinase (MAPK).Modification of substitution at positions C2 and N9 caused increased inhibitory activity of 6-benzylaminopurine analogs.In the case of 6-isopentenyladenine derivatives, the addition of a methyl group at position N9 caused at least 2-fold increased inhibitory activity, as compared with the addition of an isopropyl group. The data indicate that the selectivity and potency of inhibitors can be improved by modification of the chemical structure, suggesting that trisubstituted purines are powerful tools for probing biological processes and understanding the physiological roles of MAPK signaling.
dcterms:title
Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors
skos:prefLabel
Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors Trisubstituted Purines Are Useful Tools for Developing Potent Plant Mitogen-Activated Protein Kinase Inhibitors
skos:notation
RIV/61389030:_____/10:00357894!RIV11-GA0-61389030
n3:aktivita
n7:P n7:Z
n3:aktivity
P(GA301/08/1649), Z(AV0Z50380511), Z(MSM6198959216)
n3:cisloPeriodika
3
n3:dodaniDat
n12:2011
n3:domaciTvurceVysledku
n4:9130241 n4:4712048
n3:druhVysledku
n17:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
293641
n3:idVysledku
RIV/61389030:_____/10:00357894
n3:jazykVysledku
n18:eng
n3:klicovaSlova
mitogen-activated protein kinase (MAPK); trisubstituted purines; inhibitor
n3:klicoveSlovo
n5:mitogen-activated%20protein%20kinase%20%28MAPK%29 n5:trisubstituted%20purines n5:inhibitor
n3:kodStatuVydavatele
JP - Japonsko
n3:kontrolniKodProRIV
[C3C992DD1C8B]
n3:nazevZdroje
Biosciences Biotechnology and Biochemistry
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n14:GA301%2F08%2F1649
n3:rokUplatneniVysledku
n12:2010
n3:svazekPeriodika
74
n3:tvurceVysledku
Hyun, T. K. Havlíček, Libor Strnad, Miroslav Roitsch, T.
n3:wos
000276541600017
n3:zamer
n10:MSM6198959216 n10:AV0Z50380511
s:issn
0916-8451
s:numberOfPages
5