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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F10%3A00352737%21RIV11-GA0-61389030
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The invention relates to new pyrazolo (4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. It is an object of this invention to provide anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive compounds having improved selectivity and efficiency index, i. E. that are less toxic yet more efficacious tha analogues known heretofore. It is an object of this invention to provide 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide pharmaceutical composition, which comprises a 3,5,7-ftrisubstituted pyrazolo(4,3-d)pyrimidine and a pharmaceutically acceptable carrier. The invention relates to new pyrazolo (4,3-d)pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic methods. It is an object of this invention to provide anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive compounds having improved selectivity and efficiency index, i. E. that are less toxic yet more efficacious tha analogues known heretofore. It is an object of this invention to provide 3,5,7-trisubstituted pyrazolo(4,3-d)pyrimidines, which inhibit the cdks, cell proliferation, and/or induce apoptosis. A further object of the invention is to provide pharmaceutical composition, which comprises a 3,5,7-ftrisubstituted pyrazolo(4,3-d)pyrimidine and a pharmaceutically acceptable carrier.
dcterms:title
Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
skos:prefLabel
Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
skos:notation
RIV/61389030:_____/10:00352737!RIV11-GA0-61389030
n3:aktivita
n9:P
n3:aktivity
P(GA301/08/1649), P(GA522/09/1576)
n3:cisloPatentuVzoru
EP1348707
n3:datumUdeleniPatentuVzoru
2010-08-25+02:00
n3:dodaniDat
n12:2011
n3:domaciTvurceVysledku
n6:9896821 n6:4712048 n6:9961216 n6:1870378 n6:9130241
n3:druhVysledku
n16:P
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
283528
n3:idVysledku
RIV/61389030:_____/10:00352737
n3:jazykVysledku
n20:eng
n3:klicovaSlova
Pyrazolo[4,3-D]pyrimidines; processes; preparation; methods; therapy
n3:klicoveSlovo
n5:methods n5:preparation n5:3-D%5Dpyrimidines n5:processes n5:therapy n5:Pyrazolo%5B4
n3:kontrolniKodProRIV
[2F951CDB2F27]
n3:licencniPoplatek
n7:A
n3:mistoVydaniPatentuVzoru
Mnichov
n3:nazevVydavatelePatentuVzoru
The European Patent Office (EPO) http://v3.espacenet.com/publicationDetails/originalDocument?FT=D&date=20100825&DB=EPODOC&locale=en_EP&CC=EP&NR=1348707B1&KC=B1
n3:obor
n18:FD
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n14:GA522%2F09%2F1576 n14:GA301%2F08%2F1649
n3:rokUplatneniVysledku
n12:2010
n3:statVydaniPatentuVzoru
n19:DE
n3:tvurceVysledku
Moravcová, Daniela Lenobel, René Kryštof, Vladimír Havlíček, Libor Strnad, Miroslav
n3:uzemniOchranaPatentu
n21:A
n3:vlastnik
n8:vlastnikVysledku
n3:vyuzitiJinymSubjektem
n10:A
n3:vyuzitiPatentuVzoru
n17:B
n3:vlastnikPatentuVzoru
Ústav experimentální botaniky AV ČR, v. v. i., Univerzita Palackého v Olomouci