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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F10%3A00350394%21RIV11-GA0-61389030
rdf:type
n17:Vysledek skos:Concept
dcterms:description
The dynamic behaviour of the actin cytoskeleton in plants relies on the coordinated action of several classes of actin-binding proteins (ABPs). These ABPs include the plant-specific subfamilies of actin-nucleating formin proteins. The model plant species Arabidopsis thaliana has over 20 formin proteins, all of which contain plant-specific regions in place of the GTPase-binding domain, formin homology (FH)3 domain, and DAD and DID motifs found in many fungal and animal formins. We have identified for the first time a plant-specific region of the membrane-integrated formin AtFH4 that mediates an association with the microtubule cytoskeleton. In vitro analysis shows that this region (named the GOE domain) binds directly to microtubules. Overexpressed AtFH4 accumulates at the endoplasmic reticulum membrane and co-aligns the endoplasmic reticulum with microtubules. The FH1 and FH2 domains of formins are conserved in plants, and we show that these domains of AtFH4 nucleate F-actin. The dynamic behaviour of the actin cytoskeleton in plants relies on the coordinated action of several classes of actin-binding proteins (ABPs). These ABPs include the plant-specific subfamilies of actin-nucleating formin proteins. The model plant species Arabidopsis thaliana has over 20 formin proteins, all of which contain plant-specific regions in place of the GTPase-binding domain, formin homology (FH)3 domain, and DAD and DID motifs found in many fungal and animal formins. We have identified for the first time a plant-specific region of the membrane-integrated formin AtFH4 that mediates an association with the microtubule cytoskeleton. In vitro analysis shows that this region (named the GOE domain) binds directly to microtubules. Overexpressed AtFH4 accumulates at the endoplasmic reticulum membrane and co-aligns the endoplasmic reticulum with microtubules. The FH1 and FH2 domains of formins are conserved in plants, and we show that these domains of AtFH4 nucleate F-actin.
dcterms:title
The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain
skos:prefLabel
The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain
skos:notation
RIV/61389030:_____/10:00350394!RIV11-GA0-61389030
n3:aktivita
n4:Z n4:S n4:P
n3:aktivity
P(GAP305/10/0433), P(LC06004), S, Z(AV0Z50380511), Z(MSM0021620858)
n3:cisloPeriodika
8
n3:dodaniDat
n11:2011
n3:domaciTvurceVysledku
n7:9081186 n7:3186644
n3:druhVysledku
n16:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
279084
n3:idVysledku
RIV/61389030:_____/10:00350394
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Actin regulating proteins; Membrane; Microtubule
n3:klicoveSlovo
n10:Actin%20regulating%20proteins n10:Membrane n10:Microtubule
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[AEF29975E6AC]
n3:nazevZdroje
Journal of Cell Science
n3:obor
n12:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:projekt
n15:LC06004 n15:GAP305%2F10%2F0433
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
123
n3:tvurceVysledku
Smertenko, A. Cvrčková, F. Deeks, M. J. Žárský, Viktor Fendrych, Matyáš Hussey, P. J. Bell, K. S. Oparka, K.
n3:wos
000276568200004
n3:zamer
n13:MSM0021620858 n13:AV0Z50380511
s:issn
0021-9533
s:numberOfPages
7