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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F06%3A00082763%21RIV07-AV0-61389030
rdf:type
skos:Concept n14:Vysledek
dcterms:description
To study the structure–activity relationships of aromatic cytokinins, the cytokinin activity at both the receptor and cellular levels, as well as CDK inhibitory and anticancer properties of 38 6-benzylaminopurine (BAP) derivatives were compared in various in vitro assays. The compounds were prepared by the condensation of 6-chloropurine with corresponding substituted benzylamines. The majority of synthesised derivatives exhibited high activity in all three of the cytokinin bioassays employed (tobacco callus, wheat senescence and Amaranthus bioassay). The highest activities were obtained in the senescence bioassay. For some compounds tested, significant differences of activity were found in the bioassays used, indicating that diverse recognition systems may operate and suggesting that it may be possible to modulate particular cytokinin-dependent processes with specific compounds. Position-specific steric and hydrophobic effects of different phenyl ring substituents on the variation of biological act... To study the structure–activity relationships of aromatic cytokinins, the cytokinin activity at both the receptor and cellular levels, as well as CDK inhibitory and anticancer properties of 38 6-benzylaminopurine (BAP) derivatives were compared in various in vitro assays. The compounds were prepared by the condensation of 6-chloropurine with corresponding substituted benzylamines. The majority of synthesised derivatives exhibited high activity in all three of the cytokinin bioassays employed (tobacco callus, wheat senescence and Amaranthus bioassay). The highest activities were obtained in the senescence bioassay. For some compounds tested, significant differences of activity were found in the bioassays used, indicating that diverse recognition systems may operate and suggesting that it may be possible to modulate particular cytokinin-dependent processes with specific compounds. Position-specific steric and hydrophobic effects of different phenyl ring substituents on the variation of biological act... Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells.
dcterms:title
Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells
skos:prefLabel
Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells
skos:notation
RIV/61389030:_____/06:00082763!RIV07-AV0-61389030
n3:strany
875;884
n3:aktivita
n18:Z n18:P
n3:aktivity
P(GA203/04/1168), P(IBS4055304), Z(AV0Z50380511), Z(MSM 153100008)
n3:cisloPeriodika
3
n3:dodaniDat
n9:2007
n3:domaciTvurceVysledku
n5:9579982 n5:4012240 n5:5991803 n5:9896821 n5:9961216 n5:1749560 n5:4712048
n3:druhVysledku
n6:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
494211
n3:idVysledku
RIV/61389030:_____/06:00082763
n3:jazykVysledku
n4:eng
n3:klicovaSlova
6-Benzylaminopurine; Cytokinin; Receptor
n3:klicoveSlovo
n12:Receptor n12:Cytokinin n12:6-Benzylaminopurine
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[B1C9C0B85B02]
n3:nazevZdroje
Bioorganic Medical Chemistry
n3:obor
n13:CA
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
9
n3:projekt
n11:GA203%2F04%2F1168 n11:IBS4055304
n3:rokUplatneniVysledku
n9:2006
n3:svazekPeriodika
14
n3:tvurceVysledku
Spíchal, Lukáš Holub, Jan Fojtíková, M. Strnad, Miroslav Lenobel, René Schmülling, T. Kryštof, Vladimír Popa, Igor Doležal, Karel
n3:zamer
n8:AV0Z50380511 n8:MSM%20153100008
s:issn
0968-0896
s:numberOfPages
10