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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F02%3A56023011%21RIV%2F2003%2FGA0%2FA56003%2FN
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Analogs of aromatic cytokinins, olomoucine, roscovitine, and bohemine, were screened for their capacity in supressing hybridoma cell growth and maintaining monoclonal antibody (MAb) production. Bohemine was selected as the most promising candidate for application. Addition of bohemine at concentrations in the range of 1-10 uM resulted in a short-term arrest of growth and of MAb secretion. The short-term suppression of cell functions was followed by a significant increase of specific growth rate and of specific production rate. At 3 uM bohemine concentration a moderate enhancement of MAb yield could be observed. The steady-state viable cell density values found in semicontinuous cultures showed stimulation of cell growth in the range of micromolar concentrations of bohemine, and inhibition of growth at higher concentrations. Analogs of aromatic cytokinins, olomoucine, roscovitine, and bohemine, were screened for their capacity in supressing hybridoma cell growth and maintaining monoclonal antibody (MAb) production. Bohemine was selected as the most promising candidate for application. Addition of bohemine at concentrations in the range of 1-10 uM resulted in a short-term arrest of growth and of MAb secretion. The short-term suppression of cell functions was followed by a significant increase of specific growth rate and of specific production rate. At 3 uM bohemine concentration a moderate enhancement of MAb yield could be observed. The steady-state viable cell density values found in semicontinuous cultures showed stimulation of cell growth in the range of micromolar concentrations of bohemine, and inhibition of growth at higher concentrations.
dcterms:title
Antiproliferative and Growth-stimulating Activities of Synthetic Cytokinin Analogs. Antiproliferative and Growth-stimulating Activities of Synthetic Cytokinin Analogs.
skos:prefLabel
Antiproliferative and Growth-stimulating Activities of Synthetic Cytokinin Analogs. Antiproliferative and Growth-stimulating Activities of Synthetic Cytokinin Analogs.
skos:notation
RIV/61389030:_____/02:56023011!RIV/2003/GA0/A56003/N
n3:strany
315;319
n3:aktivita
n8:Z n8:P
n3:aktivity
P(GA301/02/0475), P(GA303/02/0875), P(OC 844.10), Z(AV0Z5038910)
n3:dodaniDat
n5:2003
n3:domaciTvurceVysledku
n10:7416113 n10:5671140 n10:9130241 n10:4712048
n3:druhVysledku
n14:C
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
638593
n3:idVysledku
RIV/61389030:_____/02:56023011
n3:jazykVysledku
n11:eng
n3:klicovaSlova
Cytokinin Analogs; Growth stimulating
n3:klicoveSlovo
n12:Cytokinin%20Analogs n12:Growth%20stimulating
n3:kontrolniKodProRIV
[3ACA4B7505E0]
n3:mistoVydani
NL
n3:nazevEdiceCisloSvazku
(1)
n3:nazevZdroje
Animal Cell Technology - Basic and Applied Aspects.
n3:obor
n18:CE
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n15:GA301%2F02%2F0475 n15:OC%20844.10 n15:GA303%2F02%2F0875
n3:rokUplatneniVysledku
n5:2002
n3:tvurceVysledku
Franěk, František Havlíček, Libor Strnad, Miroslav Siglerová, Věra
n3:zamer
n20:AV0Z5038910
s:numberOfPages
5
n9:hasPublisher
Kluwer Academic Publishers
n16:isbn
0-7923-1882-X