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Statements

Subject Item
n2:RIV%2F61389030%3A_____%2F02%3A56023002%21RIV%2F2003%2FAV0%2FA56003%2FN
rdf:type
skos:Concept n17:Vysledek
dcterms:description
This study is based on our previous findings showing that certain amino acids may protect hybridoma cells against starvation-induced apoptosis. In the present work we have screened 44 amino acids and analogs for their capacity of modulating apoptosis in human T-lymphoblastic leukemia cell line MOLT-4 exposed to starvation in a nutrient-poor medium. The panel of tested substances was found to contain not only compounds with antiapoptotic activity (e.g., L-glutamine, L-histidine, glycine, L-proline, and L-2-aminopentanoic acid), but also compounds with proapoptotic activity (e.g., L-phenylalanine, L-tryptophan, L-arginine, and L-2-aminohexanoic acid). The apoptosis-modulating effects were dependent on fine details of the structure of the compounds. A switch from antiapoptotic activity to proapoptotic activity was found between 6-ami-nohexanoic acid and 7-aminoheptanoic acid, as well as between L-2-aminopentanoic acid and L-2-aminohex-anoic acid. D-amino acids tested were without effect. This study is based on our previous findings showing that certain amino acids may protect hybridoma cells against starvation-induced apoptosis. In the present work we have screened 44 amino acids and analogs for their capacity of modulating apoptosis in human T-lymphoblastic leukemia cell line MOLT-4 exposed to starvation in a nutrient-poor medium. The panel of tested substances was found to contain not only compounds with antiapoptotic activity (e.g., L-glutamine, L-histidine, glycine, L-proline, and L-2-aminopentanoic acid), but also compounds with proapoptotic activity (e.g., L-phenylalanine, L-tryptophan, L-arginine, and L-2-aminohexanoic acid). The apoptosis-modulating effects were dependent on fine details of the structure of the compounds. A switch from antiapoptotic activity to proapoptotic activity was found between 6-ami-nohexanoic acid and 7-aminoheptanoic acid, as well as between L-2-aminopentanoic acid and L-2-aminohex-anoic acid. D-amino acids tested were without effect.
dcterms:title
Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells. Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells.
skos:prefLabel
Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells. Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells.
skos:notation
RIV/61389030:_____/02:56023002!RIV/2003/AV0/A56003/N
n3:strany
141;146
n3:aktivita
n5:P n5:Z
n3:aktivity
P(OC 844.10), Z(AV0Z5038910)
n3:cisloPeriodika
1
n3:dodaniDat
n7:2003
n3:domaciTvurceVysledku
n15:5671140 n15:8224226
n3:druhVysledku
n8:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
638512
n3:idVysledku
RIV/61389030:_____/02:56023002
n3:jazykVysledku
n16:eng
n3:klicovaSlova
amino acids; MOLT-4; apoptosis
n3:klicoveSlovo
n4:apoptosis n4:amino%20acids n4:MOLT-4
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[7FF2F47C4710]
n3:nazevZdroje
Archives of Biochemistry and Biophysics
n3:obor
n12:CE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n18:OC%20844.10
n3:rokUplatneniVysledku
n7:2002
n3:svazekPeriodika
398
n3:tvurceVysledku
Eckschlanger, T. Fismolová, Ivana Franěk, František
n3:zamer
n6:AV0Z5038910
s:issn
0003-9861
s:numberOfPages
6