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Statements

Subject Item
n2:RIV%2F61389021%3A_____%2F11%3A00369995%21RIV12-AV0-61389021
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Physical principles of novel type of generator of focused tandem shock waves with time delay between the first and second shock waves of 10 µs have been presented. Generator produces at the focus strong shock wave with peak positive pressure up to 80 MPa followed by tensile wave with peak negative pressure down up to -80 MPa, generating thus at the focus a large number of cavitation. Biological effects of FTSW were demonstrated in vitro on hemolysis of erythrocytes and cell viability of acute lymphoblastic leukemia cells, and on tumor growth delay experiments ex vivo and in vivo. Synergetic cytotoxicity of FTSW with Photosan on tumor growth was observed, possibly due to cavitation induced sonodynamic effect of FTSW. Physical principles of novel type of generator of focused tandem shock waves with time delay between the first and second shock waves of 10 µs have been presented. Generator produces at the focus strong shock wave with peak positive pressure up to 80 MPa followed by tensile wave with peak negative pressure down up to -80 MPa, generating thus at the focus a large number of cavitation. Biological effects of FTSW were demonstrated in vitro on hemolysis of erythrocytes and cell viability of acute lymphoblastic leukemia cells, and on tumor growth delay experiments ex vivo and in vivo. Synergetic cytotoxicity of FTSW with Photosan on tumor growth was observed, possibly due to cavitation induced sonodynamic effect of FTSW.
dcterms:title
Focused tandem shock waves in water and their potential application in cancer treatment Focused tandem shock waves in water and their potential application in cancer treatment
skos:prefLabel
Focused tandem shock waves in water and their potential application in cancer treatment Focused tandem shock waves in water and their potential application in cancer treatment
skos:notation
RIV/61389021:_____/11:00369995!RIV12-AV0-61389021
n3:predkladatel
n22:ico%3A61389021
n4:aktivita
n9:Z n9:P
n4:aktivity
P(GA202/09/1151), Z(AV0Z20430508)
n4:dodaniDat
n10:2012
n4:domaciTvurceVysledku
n5:8384908 n5:4439678 Stelmashuk, Vitaliy n5:5008824
n4:druhVysledku
n16:D
n4:duvernostUdaju
n6:S
n4:entitaPredkladatele
n20:predkladatel
n4:idSjednocenehoVysledku
200049
n4:idVysledku
RIV/61389021:_____/11:00369995
n4:jazykVysledku
n15:eng
n4:klicovaSlova
focused shock waves; underwater discharge; cancer treatment
n4:klicoveSlovo
n8:focused%20shock%20waves n8:underwater%20discharge n8:cancer%20treatment
n4:kontrolniKodProRIV
[E7B8FD1C44DE]
n4:mistoKonaniAkce
Manchester
n4:mistoVydani
Manchester
n4:nazevZdroje
Proceedings of 28th International Symposium on Shock Waves
n4:obor
n13:BL
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
11
n4:projekt
n14:GA202%2F09%2F1151
n4:rokUplatneniVysledku
n10:2011
n4:tvurceVysledku
Stelmashuk, Vitaliy Lukeš, Petr Tománková, K. Kolářová, H. Beneš, J. Šunka, Pavel Binder, S. Hoffer, Petr Poučková, P. Zeman, J. Dibdiak, L.
n4:typAkce
n18:WRD
n4:zahajeniAkce
2011-07-17+02:00
n4:zamer
n21:AV0Z20430508
s:numberOfPages
6
n19:hasPublisher
Springer-Verlag
n11:isbn
978-3-642-25687-5