This HTML5 document contains 49 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n10http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F61389013%3A_____%2F15%3A00439963%21RIV15-MPO-61389013/
dctermshttp://purl.org/dc/terms/
n16http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n5http://linked.opendata.cz/resource/domain/vavai/projekt/
n17http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n8http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n12http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n7http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F15%3A00439963%21RIV15-MPO-61389013
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer was prepared using two approaches. The direct copolymerization with N-methacryloyl-l-tyrosinamide, as well as end-capping of carboxy-terminated PVCL homopolymer with tyramine, were used. In both cases the product was successfully radiolabeled with 125I. The obtained polymers demonstrate cloud-point temperature (TC) values in the range of 33–35 °C in all the studied solvent systems (water, PBS (pH 7.4) and physiological saline solution). Above the cloud point temperature, the molecularly dissolved polymer is macroprecipitated from the solution. The TC values close to the human body temperature of this biocompatible poly(N-vinylcaprolactam) polymer makes it a promising material intended for local therapy of solid tumors. Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer was prepared using two approaches. The direct copolymerization with N-methacryloyl-l-tyrosinamide, as well as end-capping of carboxy-terminated PVCL homopolymer with tyramine, were used. In both cases the product was successfully radiolabeled with 125I. The obtained polymers demonstrate cloud-point temperature (TC) values in the range of 33–35 °C in all the studied solvent systems (water, PBS (pH 7.4) and physiological saline solution). Above the cloud point temperature, the molecularly dissolved polymer is macroprecipitated from the solution. The TC values close to the human body temperature of this biocompatible poly(N-vinylcaprolactam) polymer makes it a promising material intended for local therapy of solid tumors.
dcterms:title
Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications
skos:prefLabel
Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications
skos:notation
RIV/61389013:_____/15:00439963!RIV15-MPO-61389013
n3:aktivita
n15:I n15:P
n3:aktivity
I, P(FR-TI4/625), P(LH14079)
n3:cisloPeriodika
April
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
Petrova, Svetlana n16:7587562 n16:6593534 n16:9218424 n16:2540568 n16:1474545
n3:druhVysledku
n14:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
465
n3:idVysledku
RIV/61389013:_____/15:00439963
n3:jazykVysledku
n18:eng
n3:klicovaSlova
poly(N-vinylcaprolactam); tumor; brachytherapy
n3:klicoveSlovo
n12:poly%28N-vinylcaprolactam%29 n12:brachytherapy n12:tumor
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[81F16D1C52DB]
n3:nazevZdroje
Applied Radiation and Isotopes
n3:obor
n9:CD
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n5:FR-TI4%2F625 n5:LH14079
n3:rokUplatneniVysledku
n7:2015
n3:svazekPeriodika
98
n3:tvurceVysledku
Štěpánek, Petr Kučka, Jan Černochová, Zulfiya Černoch, Peter Petrova, Svetlana Hrubý, Martin
s:issn
0969-8043
s:numberOfPages
6
n8:doi
10.1016/j.apradiso.2015.01.005