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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F14%3A00437495%21RIV15-GA0-61389013
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://mmsl.cz/viCMS/soubory/pdf/MMSL_2014_4_5_WWW.pdf
dcterms:description
Polymer drug delivery systems were during last few decades proven to be efficient potential therapeutics for cancer treatment, especilly for the treatment of solid tumors, where they may take advantage of the Enhanced Permeability and Retention (EPR) effect for tumor-specific passive accumulation. Controlled release of anticancer drugs in cancer cells may be triggered by. e.g., cathepsin B activation after endocytosis. Endosomal proteases, especially cathepsins B and L, are known to be one of the key factors influencing some viral infections. For instance Ebola virus requires partial proteolysis of its surface glycoprotein for efficient endosome escape within its life cycle. We hypothesize that polymeric cathepsin B and L inhibitors may utilize advantages of polymer delivery systems for more effective treatment of viral infections with cathepsin inhibitors reducing systemic toxicity and increasing efficacy by targeted delivery of these inhibitors. Polymer drug delivery systems were during last few decades proven to be efficient potential therapeutics for cancer treatment, especilly for the treatment of solid tumors, where they may take advantage of the Enhanced Permeability and Retention (EPR) effect for tumor-specific passive accumulation. Controlled release of anticancer drugs in cancer cells may be triggered by. e.g., cathepsin B activation after endocytosis. Endosomal proteases, especially cathepsins B and L, are known to be one of the key factors influencing some viral infections. For instance Ebola virus requires partial proteolysis of its surface glycoprotein for efficient endosome escape within its life cycle. We hypothesize that polymeric cathepsin B and L inhibitors may utilize advantages of polymer delivery systems for more effective treatment of viral infections with cathepsin inhibitors reducing systemic toxicity and increasing efficacy by targeted delivery of these inhibitors.
dcterms:title
Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis
skos:prefLabel
Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis Polymer therapeutics for treatment of viral infections such as Ebola - how to teach new tricks to an old dog? A hypothesis
skos:notation
RIV/61389013:_____/14:00437495!RIV15-GA0-61389013
n3:aktivita
n12:P n12:I
n3:aktivity
I, P(7F14009), P(GA13-08336S)
n3:cisloPeriodika
4
n3:dodaniDat
n5:2015
n3:domaciTvurceVysledku
n15:2540568
n3:druhVysledku
n10:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
37418
n3:idVysledku
RIV/61389013:_____/14:00437495
n3:jazykVysledku
n7:eng
n3:klicovaSlova
Ebola virus; cathepsin; polymer
n3:klicoveSlovo
n4:polymer n4:cathepsin n4:Ebola%20virus
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[E811181D25A5]
n3:nazevZdroje
Military Medical Science Letters
n3:obor
n16:EE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:projekt
n13:7F14009 n13:GA13-08336S
n3:rokUplatneniVysledku
n5:2014
n3:svazekPeriodika
83
n3:tvurceVysledku
Hrubý, Martin
s:issn
0372-7025
s:numberOfPages
5