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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F14%3A00429950%21RIV15-GA0-61389013
rdf:type
n16:Vysledek skos:Concept
dcterms:description
In this report, hierarchically structured diblock copolymer brushes are shown as an effective alternative to limit the increase in fouling caused by the activation of functional groups for the attachment of biorecognition elements. The growth of antifouling diblock copolymer brushes containing hydroxyl- and carboxy-functional top blocks was enabled by the utilization of surface-initiated atom transfer radical polymerization. The fouling from blood plasma is minimized, which is an essential property for the applications of these surfaces in label-free affinity biosensors for medical diagnostics and other fields that involve complex biological matrices. Furthermore, the increase in fouling associated with the activation of functional groups was significantly lowered. The use of a top block consisting of poly(carboxybetaine acrylamide) displays improved performance relative to a hydroxyl-bearing polymer after activation. A biosensor able to detect a targeted protein spiked in undiluted blood plasma is presented as a proof of concept. In this report, hierarchically structured diblock copolymer brushes are shown as an effective alternative to limit the increase in fouling caused by the activation of functional groups for the attachment of biorecognition elements. The growth of antifouling diblock copolymer brushes containing hydroxyl- and carboxy-functional top blocks was enabled by the utilization of surface-initiated atom transfer radical polymerization. The fouling from blood plasma is minimized, which is an essential property for the applications of these surfaces in label-free affinity biosensors for medical diagnostics and other fields that involve complex biological matrices. Furthermore, the increase in fouling associated with the activation of functional groups was significantly lowered. The use of a top block consisting of poly(carboxybetaine acrylamide) displays improved performance relative to a hydroxyl-bearing polymer after activation. A biosensor able to detect a targeted protein spiked in undiluted blood plasma is presented as a proof of concept.
dcterms:title
Hierarchical antifouling brushes for biosensing applications Hierarchical antifouling brushes for biosensing applications
skos:prefLabel
Hierarchical antifouling brushes for biosensing applications Hierarchical antifouling brushes for biosensing applications
skos:notation
RIV/61389013:_____/14:00429950!RIV15-GA0-61389013
n4:aktivita
n15:I n15:P
n4:aktivity
I, P(ED1.1.00/02.0109), P(EE2.3.30.0029), P(GAP205/12/1702)
n4:cisloPeriodika
31 October
n4:dodaniDat
n9:2015
n4:domaciTvurceVysledku
Rodriguez-Emmenegger, Cesar de los Santos Pereira, Andres n13:1778013 n13:2239272
n4:druhVysledku
n17:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
19032
n4:idVysledku
RIV/61389013:_____/14:00429950
n4:jazykVysledku
n11:eng
n4:klicovaSlova
hierarchically structured brushes; affinity biosensors; fouling
n4:klicoveSlovo
n6:hierarchically%20structured%20brushes n6:affinity%20biosensors n6:fouling
n4:kodStatuVydavatele
CH - Švýcarská konfederace
n4:kontrolniKodProRIV
[003799B85285]
n4:nazevZdroje
Sensors and Actuators B - Chemical
n4:obor
n14:CE
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
4
n4:projekt
n8:GAP205%2F12%2F1702 n8:EE2.3.30.0029 n8:ED1.1.00%2F02.0109
n4:rokUplatneniVysledku
n9:2014
n4:svazekPeriodika
202
n4:tvurceVysledku
de los Santos Pereira, Andres Brynda, Eduard Rodriguez-Emmenegger, Cesar Riedel, Tomáš
n4:wos
000339994900168
s:issn
0925-4005
s:numberOfPages
9
n12:doi
10.1016/j.snb.2014.06.075