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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F14%3A00424588%21RIV14-AV0-61389013
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Various click chemistry azide–alkyne cycloaddition reactions were used to attach azide group-terminated peptides to polymer drug carriers in an effort to conjugate biologically active molecules with polymer drug carriers by directly binding unprotected peptides to these polymers. Three methods using click chemistry to conjugate the azide group-containing molecules with synthetic polymers were compared: (1) click chemistry with a Cu(I) catalyst in aqueous and organic solvents, (2) click reactions using ruthenium complex catalysts in DMF and (3) metal-free click chemistry based on a dibenzocyclooctyne (DBCO) reactive group. The suitability of these reactions was verified for the non-covalent attachment of targeting moieties to these polymer carriers via peptide–peptide interactions. Moreover, RAFT polymerization was suggested for the synthesis of semitelechelic copolymers containing a single DBCO group at the polymer chain end and for the preparation of well-defined diblock copolymer drug carriers consisting of specific peptide and hydrophilic polymer blocks. Various click chemistry azide–alkyne cycloaddition reactions were used to attach azide group-terminated peptides to polymer drug carriers in an effort to conjugate biologically active molecules with polymer drug carriers by directly binding unprotected peptides to these polymers. Three methods using click chemistry to conjugate the azide group-containing molecules with synthetic polymers were compared: (1) click chemistry with a Cu(I) catalyst in aqueous and organic solvents, (2) click reactions using ruthenium complex catalysts in DMF and (3) metal-free click chemistry based on a dibenzocyclooctyne (DBCO) reactive group. The suitability of these reactions was verified for the non-covalent attachment of targeting moieties to these polymer carriers via peptide–peptide interactions. Moreover, RAFT polymerization was suggested for the synthesis of semitelechelic copolymers containing a single DBCO group at the polymer chain end and for the preparation of well-defined diblock copolymer drug carriers consisting of specific peptide and hydrophilic polymer blocks.
dcterms:title
Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers
skos:prefLabel
Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers
skos:notation
RIV/61389013:_____/14:00424588!RIV14-AV0-61389013
n13:predkladatel
n14:ico%3A61389013
n3:aktivita
n17:I
n3:aktivity
I
n3:cisloPeriodika
4
n3:dodaniDat
n12:2014
n3:domaciTvurceVysledku
n9:6656153 n9:4763173 n9:2219174 n9:5536898 n9:5292964
n3:druhVysledku
n7:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
7489
n3:idVysledku
RIV/61389013:_____/14:00424588
n3:jazykVysledku
n15:eng
n3:klicovaSlova
click chemistry; RAFT polymerization; hydrophilic polymers
n3:klicoveSlovo
n6:hydrophilic%20polymers n6:RAFT%20polymerization n6:click%20chemistry
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[D26E0D61CACE]
n3:nazevZdroje
Polymer Chemistry
n3:obor
n8:CD
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
5
n3:tvurceVysledku
Laga, Richard Braunová, Alena Pechar, Michal Ulbrich, Karel Pola, Robert
n3:wos
000331343100026
s:issn
1759-9954
s:numberOfPages
11
n18:doi
10.1039/C3PY01376F