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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F13%3A00399466%21RIV14-GA0-61389013
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (RH) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGA PNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer–solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase. Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (RH) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGA PNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer–solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase.
dcterms:title
Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward
skos:prefLabel
Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward
skos:notation
RIV/61389013:_____/13:00399466!RIV14-GA0-61389013
n11:predkladatel
n19:ico%3A61389013
n4:aktivita
n15:P n15:I
n4:aktivity
I, P(GA202/09/2078)
n4:cisloPeriodika
5 September
n4:dodaniDat
n14:2014
n4:domaciTvurceVysledku
n10:1474545 Jäger, Eliezer Jäger, Alessandro
n4:druhVysledku
n16:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
96193
n4:idVysledku
RIV/61389013:_____/13:00399466
n4:jazykVysledku
n7:eng
n4:klicovaSlova
sub-100 nm polymeric nanoparticles; light scattering; nanoprecipitation
n4:klicoveSlovo
n13:sub-100%20nm%20polymeric%20nanoparticles n13:light%20scattering n13:nanoprecipitation
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[2B2583CAB4EC]
n4:nazevZdroje
Colloids and Surfaces. A - Physicochemical and Engineering Aspects
n4:obor
n6:BO
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
5
n4:projekt
n8:GA202%2F09%2F2078
n4:rokUplatneniVysledku
n14:2013
n4:svazekPeriodika
436
n4:tvurceVysledku
Giacomelli, F. C. Jäger, Eliezer Jäger, Alessandro Štěpánek, Petr de Oliveira, A. M.
n4:wos
000326416900135
s:issn
0927-7757
s:numberOfPages
11
n12:doi
10.1016/j.colsurfa.2013.08.056