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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F13%3A00391930%21RIV14-MSM-61389013
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Gamma-Fe2O3 nanoparticles obtained by coprecipitation of Fe(II) and Fe(III) chlorides with a base and subsequent oxidation were coated with a shell of hydrophilic biocompatible poly(N,N-dimethylacrylamide) (PDMAAm). Various initiators were attached to the iron oxide surface to enable the use of the “grafting-from“ approach for immobilization of PDMAAm. They included 2,2-azobis(2-methylpropanimidamide) dihydrochloride (AMPA), 2,2-azobis(N-hydroxy-2-methylpropanimidamide) dihydrochloride (ABHA) and 4-cyano-4-{[1-cyano-3-(N-hydroxycarbamoyl)-1-methylpropyl]azo}pentanoic acid (CCHPA). Engulfment of PDMAAm-coated γ-Fe2O3 nanoparticles by murine J774.2 macrophages was investigated. Only some nanoparticles were engulfed by the macrophages. PDMAAm-AMPA-γ-Fe2O3 and PDMAAm-ABHA-γ-Fe2O3 nanoparticles were rapidly engulfed by the cells. In contrast, neat γ-Fe2O3 and PDMAAm-CCHPA-γ-Fe2O3 particles induced formation of transparent vacuoles indicating toxicity of the particles. Thus, PDMAAm-coated AMPA- and ABHA-γ-Fe2O3 nanoparticles can be recommended as non-toxic labels for mammalian cells. Gamma-Fe2O3 nanoparticles obtained by coprecipitation of Fe(II) and Fe(III) chlorides with a base and subsequent oxidation were coated with a shell of hydrophilic biocompatible poly(N,N-dimethylacrylamide) (PDMAAm). Various initiators were attached to the iron oxide surface to enable the use of the “grafting-from“ approach for immobilization of PDMAAm. They included 2,2-azobis(2-methylpropanimidamide) dihydrochloride (AMPA), 2,2-azobis(N-hydroxy-2-methylpropanimidamide) dihydrochloride (ABHA) and 4-cyano-4-{[1-cyano-3-(N-hydroxycarbamoyl)-1-methylpropyl]azo}pentanoic acid (CCHPA). Engulfment of PDMAAm-coated γ-Fe2O3 nanoparticles by murine J774.2 macrophages was investigated. Only some nanoparticles were engulfed by the macrophages. PDMAAm-AMPA-γ-Fe2O3 and PDMAAm-ABHA-γ-Fe2O3 nanoparticles were rapidly engulfed by the cells. In contrast, neat γ-Fe2O3 and PDMAAm-CCHPA-γ-Fe2O3 particles induced formation of transparent vacuoles indicating toxicity of the particles. Thus, PDMAAm-coated AMPA- and ABHA-γ-Fe2O3 nanoparticles can be recommended as non-toxic labels for mammalian cells.
dcterms:title
The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells
skos:prefLabel
The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells The use of hydrophilic poly(N,N-dimethylacrylamide) for promoting engulfment of magnetic .gamma.-Fe2O3 nanoparticles by mammalian cells
skos:notation
RIV/61389013:_____/13:00391930!RIV14-MSM-61389013
n15:predkladatel
n18:ico%3A61389013
n3:aktivita
n5:P n5:I
n3:aktivity
I, P(7E12053), P(GAP206/12/0381)
n3:cisloPeriodika
3
n3:dodaniDat
n16:2014
n3:domaciTvurceVysledku
n6:6338135 n6:8893756 n6:8306273 n6:5920647 Zasońska, Beata Anna n6:6335608 n6:6116094
n3:druhVysledku
n9:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
112994
n3:idVysledku
RIV/61389013:_____/13:00391930
n3:jazykVysledku
n14:eng
n3:klicovaSlova
maghemite; core-shell; nanoparticles
n3:klicoveSlovo
n10:core-shell n10:nanoparticles n10:maghemite
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[BDDF696360AE]
n3:nazevZdroje
Journal of Biomedical Nanotechnology
n3:obor
n12:CD
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
10
n3:projekt
n11:7E12053 n11:GAP206%2F12%2F0381
n3:rokUplatneniVysledku
n16:2013
n3:svazekPeriodika
9
n3:tvurceVysledku
Hromádková, Jiřina Klyuchivska, O. Babič, Michal Zasońska, Beata Anna Horák, Daniel Boiko, N. Beneš, Milan J. Macková, Hana Stoika, R. Trchová, Miroslava
n3:wos
000316040500019
s:issn
1550-7033
s:numberOfPages
13
n17:doi
10.1166/jbn.2013.1552