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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F13%3A00388063%21RIV13-AV0-61389013
rdf:type
n3:Vysledek skos:Concept
dcterms:description
The coiled coil is a superhelical structural protein motif that has been thoroughly investigated in recent years. Because of the relatively well-understood principles that determine the properties of coiled coil peptides and proteins, macromolecular systems containing the coiled coil motif have been suggested for various applications. This short review focuses on hybrid polymer coiled coil systems designed for drug delivery purposes. After a short introduction, the most important features of the coiled coils (stability, association number, oligomerization selectivity and orientation of helices) are described, and the factors influencing these characteristics are discussed. Several examples of the most interesting biomedical applications of the polymer-coiled coil systems (according to the authors' opinion) are presented. The coiled coil is a superhelical structural protein motif that has been thoroughly investigated in recent years. Because of the relatively well-understood principles that determine the properties of coiled coil peptides and proteins, macromolecular systems containing the coiled coil motif have been suggested for various applications. This short review focuses on hybrid polymer coiled coil systems designed for drug delivery purposes. After a short introduction, the most important features of the coiled coils (stability, association number, oligomerization selectivity and orientation of helices) are described, and the factors influencing these characteristics are discussed. Several examples of the most interesting biomedical applications of the polymer-coiled coil systems (according to the authors' opinion) are presented.
dcterms:title
The coiled coil motif in polymer drug delivery systems The coiled coil motif in polymer drug delivery systems
skos:prefLabel
The coiled coil motif in polymer drug delivery systems The coiled coil motif in polymer drug delivery systems
skos:notation
RIV/61389013:_____/13:00388063!RIV13-AV0-61389013
n3:predkladatel
n16:ico%3A61389013
n4:aktivita
n5:P n5:Z
n4:aktivity
P(1M0505), P(GA203/08/0543), Z(AV0Z40500505)
n4:cisloPeriodika
1
n4:dodaniDat
n18:2013
n4:domaciTvurceVysledku
n15:5292964 n15:2219174
n4:druhVysledku
n6:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
65894
n4:idVysledku
RIV/61389013:_____/13:00388063
n4:jazykVysledku
n12:eng
n4:klicovaSlova
coiled coil; hydrophilic polymer; recombinant protein
n4:klicoveSlovo
n9:recombinant%20protein n9:coiled%20coil n9:hydrophilic%20polymer
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[0EC3A673AE1D]
n4:nazevZdroje
Biotechnology Advances
n4:obor
n17:CD
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
2
n4:projekt
n14:GA203%2F08%2F0543 n14:1M0505
n4:rokUplatneniVysledku
n18:2013
n4:svazekPeriodika
31
n4:tvurceVysledku
Pechar, Michal Pola, Robert
n4:wos
000315761200009
n4:zamer
n8:AV0Z40500505
s:issn
0734-9750
s:numberOfPages
7
n20:doi
10.1016/j.biotechadv.2012.01.003