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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F12%3A00384590%21RIV13-AV0-61389013
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Intravenous delivery of therapeutic virus particles remains a major goal for virotherapy of metastatic cancer. Polymer coating of adenovirus type 5 (Ad5) can combine with predosing strategies or Kupffer cell ablation to achieve systemic kinetics with a half-life >60 min, allowing ready access to peripheral tumors. Polymer coating wild-type Ad5 in this way is known to decrease hepatic toxicity, increasing the dose of virus particles that can be safely administered. Using polymer-coating technology to deliver a replicating Ad5 systemically, virus replication and transgene expression was almost totally confined to tumor tissues, giving a much improved therapeutic index compared with uncoated virus, and complete control of human HepG2 tumor xenografts. Intravenous delivery of therapeutic virus particles remains a major goal for virotherapy of metastatic cancer. Polymer coating of adenovirus type 5 (Ad5) can combine with predosing strategies or Kupffer cell ablation to achieve systemic kinetics with a half-life >60 min, allowing ready access to peripheral tumors. Polymer coating wild-type Ad5 in this way is known to decrease hepatic toxicity, increasing the dose of virus particles that can be safely administered. Using polymer-coating technology to deliver a replicating Ad5 systemically, virus replication and transgene expression was almost totally confined to tumor tissues, giving a much improved therapeutic index compared with uncoated virus, and complete control of human HepG2 tumor xenografts.
dcterms:title
Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer
skos:prefLabel
Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer
skos:notation
RIV/61389013:_____/12:00384590!RIV13-AV0-61389013
n13:predkladatel
n15:ico%3A61389013
n3:aktivita
n9:Z n9:I n9:P
n3:aktivity
I, P(IAAX00500803), Z(AV0Z40500505)
n3:cisloPeriodika
11
n3:dodaniDat
n11:2013
n3:domaciTvurceVysledku
n19:8642710 n19:4763173
n3:druhVysledku
n20:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
175240
n3:idVysledku
RIV/61389013:_____/12:00384590
n3:jazykVysledku
n14:eng
n3:klicovaSlova
clodronate liposomes; polymer-coated adenovirus; predosing strategy
n3:klicoveSlovo
n8:predosing%20strategy n8:clodronate%20liposomes n8:polymer-coated%20adenovirus
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[418CADABE9A4]
n3:nazevZdroje
Nanomedicine
n3:obor
n5:CD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
11
n3:projekt
n6:IAAX00500803
n3:rokUplatneniVysledku
n11:2012
n3:svazekPeriodika
7
n3:tvurceVysledku
Cawood, R. Šubr, Vladimír Seymour, L. W. Fisher, K. D. Green, N. K. van Rooijen, N. Ulbrich, Karel Herbert, C. Illingworth, S. Hermiston, T. Hale, A.
n3:wos
000311329700013
n3:zamer
n4:AV0Z40500505
s:issn
1743-5889
s:numberOfPages
13
n17:doi
10.2217/NNM.12.50