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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F12%3A00376432%21RIV13-AV0-61389013
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Various biodegradable micellar polymer drug carriers based on N -(2-hydroxypropyl)methacrylamide copolymers and their conjugates with doxorubicin are synthesized. The conjugates are designed to treat solid tumors and subsequently to allow carrier elimination from the body. All copolymers self-assemble in aqueous solution into supramolecular structures with highly hydrophobic cholesterol derivatives in the core and doxorubicin located in the hydrophilic shell. The drug is released quickly from the micelles incubated at pH = 5.0 (modelling the endosomes of tumor cells). Slower release of cholesterol derivatives leading to disintegration of the micelles is observed. Various biodegradable micellar polymer drug carriers based on N -(2-hydroxypropyl)methacrylamide copolymers and their conjugates with doxorubicin are synthesized. The conjugates are designed to treat solid tumors and subsequently to allow carrier elimination from the body. All copolymers self-assemble in aqueous solution into supramolecular structures with highly hydrophobic cholesterol derivatives in the core and doxorubicin located in the hydrophilic shell. The drug is released quickly from the micelles incubated at pH = 5.0 (modelling the endosomes of tumor cells). Slower release of cholesterol derivatives leading to disintegration of the micelles is observed.
dcterms:title
Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors
skos:prefLabel
Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors Hydrolytically degradable polymer micelles for anticancer drug delivery to solid tumors
skos:notation
RIV/61389013:_____/12:00376432!RIV13-AV0-61389013
n16:predkladatel
n18:ico%3A61389013
n4:aktivita
n8:P n8:Z
n4:aktivity
P(GAP301/11/0325), P(IAAX00500803), Z(AV0Z40500505)
n4:cisloPeriodika
8
n4:dodaniDat
n15:2013
n4:domaciTvurceVysledku
n9:8890390 n9:6390137 n9:4763173 n9:9442286
n4:druhVysledku
n19:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
140058
n4:idVysledku
RIV/61389013:_____/12:00376432
n4:jazykVysledku
n20:eng
n4:klicovaSlova
HPMA copolymers; drug delivery systems; doxorubicin
n4:klicoveSlovo
n6:doxorubicin n6:HPMA%20copolymers n6:drug%20delivery%20systems
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[CC3A55CD05B4]
n4:nazevZdroje
Macromolecular Chemistry and Physics
n4:obor
n5:EC
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
4
n4:projekt
n14:GAP301%2F11%2F0325 n14:IAAX00500803
n4:rokUplatneniVysledku
n15:2012
n4:svazekPeriodika
213
n4:tvurceVysledku
Etrych, Tomáš Ulbrich, Karel Kostka, Libor Chytil, Petr
n4:wos
000302912300008
n4:zamer
n11:AV0Z40500505
s:issn
1022-1352
s:numberOfPages
10
n17:doi
10.1002/macp.201100632