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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F12%3A00376255%21RIV13-AV0-61389013
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Preclinical in vivo characterization of new polymeric drug conjugate candidates is crucial for understanding the effects of certain chemical modifications on distribution and elimination of these carrier systems, which is the basis for rational drug design. In our study we synthesized dual fluorescent HPMA copolymers of different architectures and molecular weights, containing one fluorescent dye coupled via a stable hydrazide bond functioning as the carrier label and the other one modeling the drug bound to a carrier via a pH-sensitive hydrolytically cleavable hydrazone bond. Thus, it was possible to track the in vivo fate of the polymer drug carrier and a cleavable model drug simultaneously and noninvasively in nude mice using multispectral optical imaging. We confirmed our in vivo results by more detailed ex vivo characterization (imaging and microscopy) of autopsied organs and tumors. We observed a moderate accumulation of the polymeric carriers in the tumors. Preclinical in vivo characterization of new polymeric drug conjugate candidates is crucial for understanding the effects of certain chemical modifications on distribution and elimination of these carrier systems, which is the basis for rational drug design. In our study we synthesized dual fluorescent HPMA copolymers of different architectures and molecular weights, containing one fluorescent dye coupled via a stable hydrazide bond functioning as the carrier label and the other one modeling the drug bound to a carrier via a pH-sensitive hydrolytically cleavable hydrazone bond. Thus, it was possible to track the in vivo fate of the polymer drug carrier and a cleavable model drug simultaneously and noninvasively in nude mice using multispectral optical imaging. We confirmed our in vivo results by more detailed ex vivo characterization (imaging and microscopy) of autopsied organs and tumors. We observed a moderate accumulation of the polymeric carriers in the tumors.
dcterms:title
Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging
skos:prefLabel
Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging
skos:notation
RIV/61389013:_____/12:00376255!RIV13-AV0-61389013
n17:predkladatel
n19:ico%3A61389013
n3:aktivita
n15:P n15:Z
n3:aktivity
P(GAP301/11/0325), P(IAAX00500803), Z(AV0Z40500505)
n3:cisloPeriodika
3
n3:dodaniDat
n11:2013
n3:domaciTvurceVysledku
n4:4763173 n4:8890390 n4:9387501
n3:druhVysledku
n9:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
132278
n3:idVysledku
RIV/61389013:_____/12:00376255
n3:jazykVysledku
n20:eng
n3:klicovaSlova
fluorescence dyes; star-like HPMA polymer carriers; diagnostics of tumors
n3:klicoveSlovo
n16:diagnostics%20of%20tumors n16:star-like%20HPMA%20polymer%20carriers n16:fluorescence%20dyes
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[869F2EC56553]
n3:nazevZdroje
Biomacromolecules
n3:obor
n12:EC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
7
n3:projekt
n13:GAP301%2F11%2F0325 n13:IAAX00500803
n3:rokUplatneniVysledku
n11:2012
n3:svazekPeriodika
13
n3:tvurceVysledku
Mäder, K. Caysa, H. Hoffmann, S. Müller, T. Ulbrich, Karel Etrych, Tomáš Vystrčilová, Lucie
n3:wos
000301318100010
n3:zamer
n14:AV0Z40500505
s:issn
1525-7797
s:numberOfPages
12
n10:doi
10.1021/bm2015027