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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F11%3A00359453%21RIV12-AV0-61389013
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium. Reductively biodegradable hydrogels based on poly[N-(2-hydroxypropyl)methacrylamide] crosslinked with N-[3-(methacryloylamino)propyl] -6-{[5-({[3-(methacryloylamino)propyl]amino}carbonyl)-2-pyridyl]disulfanyl}nicotinamide intended for tissue engineering were synthesized and characterized. The rate of irreversible reductive degradation with thiol l-cysteine (a model of human body where several thiols are present in extracellular space) was studied using several l-cysteine concentrations. The mechanism of the irreversible reductive bond cleavage in the crosslinker structure was confirmed on a low-molecular-weight model. The hydrogel is stable during storage in phosphate buffered saline and is degraded relatively quickly in a concentration-dependent manner after addition of l-cysteine to the surrounding medium.
dcterms:title
A new type of irreversibly reductively biodegradable hydrogel A new type of irreversibly reductively biodegradable hydrogel
skos:prefLabel
A new type of irreversibly reductively biodegradable hydrogel A new type of irreversibly reductively biodegradable hydrogel
skos:notation
RIV/61389013:_____/11:00359453!RIV12-AV0-61389013
n12:predkladatel
n13:ico%3A61389013
n3:aktivita
n16:Z n16:P
n3:aktivity
P(1M0538), P(GAP108/10/1560), P(GPP207/10/P054), Z(AV0Z40500505)
n3:cisloPeriodika
5
n3:dodaniDat
n14:2012
n3:domaciTvurceVysledku
n17:5928303 n17:2790130 Vetrík, Miroslav n17:2540568
n3:druhVysledku
n19:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
183982
n3:idVysledku
RIV/61389013:_____/11:00359453
n3:jazykVysledku
n6:eng
n3:klicovaSlova
biodegradable hydrogel; disulfide; L-cysteine
n3:klicoveSlovo
n9:L-cysteine n9:disulfide n9:biodegradable%20hydrogel
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[A49201EDF047]
n3:nazevZdroje
Polymer Degradation and Stability
n3:obor
n15:CD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n5:GPP207%2F10%2FP054 n5:1M0538 n5:GAP108%2F10%2F1560
n3:rokUplatneniVysledku
n14:2011
n3:svazekPeriodika
96
n3:tvurceVysledku
Přádný, Martin Vetrík, Miroslav Michálek, Jiří Hrubý, Martin
n3:wos
000290078200021
n3:zamer
n7:AV0Z40500505
s:issn
0141-3910
s:numberOfPages
6
n20:doi
10.1016/j.polymdegradstab.2011.01.037