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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F10%3A00342223%21RIV11-MSM-61389013
rdf:type
n7:Vysledek skos:Concept
dcterms:description
We have synthesized and characterized a thermoresponsive micellar radionuclide delivery systems based on ABA triblock copolymers poly[2-methyl-2-oxazoline - block - (2-isopropyl-2-oxazoline - co - 2-butyl-2-oxazoline) - block - 2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below cloud point temperature (CPT) of the thermoresponsive central block and above its CPT they form polymer micelles with diameter 200 nm. A phenolic moiety introduced into the copolymer allowed radionuclide labeling with 125I ongoing in good yield with sufficient in vitro stability under model conditions. We have synthesized and characterized a thermoresponsive micellar radionuclide delivery systems based on ABA triblock copolymers poly[2-methyl-2-oxazoline - block - (2-isopropyl-2-oxazoline - co - 2-butyl-2-oxazoline) - block - 2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below cloud point temperature (CPT) of the thermoresponsive central block and above its CPT they form polymer micelles with diameter 200 nm. A phenolic moiety introduced into the copolymer allowed radionuclide labeling with 125I ongoing in good yield with sufficient in vitro stability under model conditions.
dcterms:title
Thermoresponsive micelles for radionuclide delivery Thermoresponsive micelles for radionuclide delivery
skos:prefLabel
Thermoresponsive micelles for radionuclide delivery Thermoresponsive micelles for radionuclide delivery
skos:notation
RIV/61389013:_____/10:00342223!RIV11-MSM-61389013
n3:aktivita
n9:P n9:Z
n3:aktivity
P(1M0505), P(GPP207/10/P054), P(KAN200200651), Z(AV0Z40500505)
n3:dodaniDat
n8:2011
n3:domaciTvurceVysledku
n4:2095653 Filippov, Sergey n4:2540568 n4:8306273 n4:4763173 n4:7899114 n4:6593534
n3:druhVysledku
n14:D
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
292790
n3:idVysledku
RIV/61389013:_____/10:00342223
n3:jazykVysledku
n11:eng
n3:klicovaSlova
micelles; drug delivery systems; thermoresponsive polymers
n3:klicoveSlovo
n6:drug%20delivery%20systems n6:thermoresponsive%20polymers n6:micelles
n3:kontrolniKodProRIV
[365C3EE5032F]
n3:mistoKonaniAkce
Egmond aan Zee
n3:mistoVydani
Egmond aan Zee
n3:nazevZdroje
Abstract Book
n3:obor
n19:FR
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n10:GPP207%2F10%2FP054 n10:KAN200200651 n10:1M0505
n3:rokUplatneniVysledku
n8:2010
n3:tvurceVysledku
Ulbrich, Karel Macková, Hana Filippov, Sergey Kučka, Jan Pánek, Jiří Hrubý, Martin Nováková, Michaela
n3:typAkce
n13:WRD
n3:zahajeniAkce
2010-04-07+02:00
n3:zamer
n18:AV0Z40500505
s:numberOfPages
3
n15:hasPublisher
University of Twente
n21:isbn
978-90-365-3007-1