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Statements

Subject Item
n2:RIV%2F61389013%3A_____%2F04%3A00101286%21RIV%2F2005%2FAV0%2FA55005%2FN
rdf:type
skos:Concept n9:Vysledek
dcterms:description
Polykationty obsahující primární a terciární amino a kvarterní amoniové skupiny tvoří stabilní komplexy s DNA pouze v čisté vodě. S rostoucí koncentrací chloridu sodného docházelo k disociaci polyplexů a uvolnění DNA. Stabilita komplexů klesala v pořadí primární > sekundární > terciární > kvarterní amoniová skupina. Výsledky počítačového modelování interakcí oligokationtu s modelem řetězce DNA byly v dobrém souhlasu s experimentálními daty. Polycations containing primary and tertiary amino and quaternary ammonium groups formed stable complexes with DNA only in pure water. Increasing concentration of sodium chloride in the saline solution resulted in dissociation, decomposition of the polyplexes and release of incorporated DNA. Stability of the complexes decreased depending on polycation substituent as follows: primary amine > secondary amine > tertiary amine >quaternary ammonium group. Results of computer modeling of the interaction of the oligocations with a model DNA chain were in good agreement with the experimental data. Polycations containing primary and tertiary amino and quaternary ammonium groups formed stable complexes with DNA only in pure water. Increasing concentration of sodium chloride in the saline solution resulted in dissociation, decomposition of the polyplexes and release of incorporated DNA. Stability of the complexes decreased depending on polycation substituent as follows: primary amine > secondary amine > tertiary amine >quaternary ammonium group. Results of computer modeling of the interaction of the oligocations with a model DNA chain were in good agreement with the experimental data.
dcterms:title
Stability of polycation-DNA complexes: comparison of computer model and experimental data Stabilita komplexů polykationt-DNA: porovnání počítačového modelu a experimentálních dat Stability of polycation-DNA complexes: comparison of computer model and experimental data
skos:prefLabel
Stability of polycation-DNA complexes: comparison of computer model and experimental data Stability of polycation-DNA complexes: comparison of computer model and experimental data Stabilita komplexů polykationt-DNA: porovnání počítačového modelu a experimentálních dat
skos:notation
RIV/61389013:_____/04:00101286!RIV/2005/AV0/A55005/N
n4:strany
3;6
n4:aktivita
n16:Z n16:P
n4:aktivity
P(KSK4055109), Z(AV0Z4050913)
n4:cisloPeriodika
1
n4:dodaniDat
n11:2005
n4:domaciTvurceVysledku
n5:1518755 n5:4802535 n5:4763173 n5:3675637
n4:druhVysledku
n18:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
587703
n4:idVysledku
RIV/61389013:_____/04:00101286
n4:jazykVysledku
n17:eng
n4:klicovaSlova
polycation-DNA complexes;gene delivery;quantum mechanical calculations
n4:klicoveSlovo
n6:gene%20delivery n6:quantum%20mechanical%20calculations n6:polycation-DNA%20complexes
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[B82FBAAB526B]
n4:nazevZdroje
Materials Structure
n4:obor
n14:CC
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
5
n4:projekt
n12:KSK4055109
n4:rokUplatneniVysledku
n11:2004
n4:svazekPeriodika
11
n4:tvurceVysledku
Huml, Karel Kabeláč, Martin Dybal, Jiří Ulbrich, Karel Reschel, Tomáš
n4:zamer
n10:AV0Z4050913
s:issn
1211-5894
s:numberOfPages
4