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Statements

Subject Item
n2:RIV%2F61388980%3A_____%2F12%3A00434349%21RIV15-AV0-61388980
rdf:type
skos:Concept n18:Vysledek
dcterms:description
The absorption, distribution, biotransformation and excretion of a drug involve its transport across cell membranes. This process is essential and influenced by the characteristics of the drug, especially its molecular size and shape, solubility at the site of its absorption, relative lipid solubility, etc. One of the progressive ways for increasing bioavaibility is a nanoparticle preparation technique. Cholesterol, cholestenolone and pregnenolone acetate as model active pharmaceutical ingredients and some of the commonly used excipients as nanoparticle stabilizers were used in the investigated precipitation method that was modified and simplified and can be used as an effective and an affordable technique for the preparation of nanoparticles. All 120 prepared samples were analyzed by means of dynamic light scattering (Nanophox). The range of the particle size of the determined 100 nanoparticle samples was from 1 nm to 773 nm, whereas 82 samples contained nanoparticles of less than 200 nm. Relationships between solvents and used excipients and their amount are discussed. The absorption, distribution, biotransformation and excretion of a drug involve its transport across cell membranes. This process is essential and influenced by the characteristics of the drug, especially its molecular size and shape, solubility at the site of its absorption, relative lipid solubility, etc. One of the progressive ways for increasing bioavaibility is a nanoparticle preparation technique. Cholesterol, cholestenolone and pregnenolone acetate as model active pharmaceutical ingredients and some of the commonly used excipients as nanoparticle stabilizers were used in the investigated precipitation method that was modified and simplified and can be used as an effective and an affordable technique for the preparation of nanoparticles. All 120 prepared samples were analyzed by means of dynamic light scattering (Nanophox). The range of the particle size of the determined 100 nanoparticle samples was from 1 nm to 773 nm, whereas 82 samples contained nanoparticles of less than 200 nm. Relationships between solvents and used excipients and their amount are discussed.
dcterms:title
Primary Investigation of the Preparation of Nanoparticles by Precipitation Primary Investigation of the Preparation of Nanoparticles by Precipitation
skos:prefLabel
Primary Investigation of the Preparation of Nanoparticles by Precipitation Primary Investigation of the Preparation of Nanoparticles by Precipitation
skos:notation
RIV/61388980:_____/12:00434349!RIV15-AV0-61388980
n3:aktivita
n16:P n16:I
n3:aktivity
I, P(GAP304/11/2246)
n3:cisloPeriodika
9
n3:dodaniDat
n6:2015
n3:domaciTvurceVysledku
n17:3149722
n3:druhVysledku
n13:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
161656
n3:idVysledku
RIV/61388980:_____/12:00434349
n3:jazykVysledku
n5:eng
n3:klicovaSlova
steroids; nanoparticles; precipitation; excipients; dynamic light scattering
n3:klicoveSlovo
n10:dynamic%20light%20scattering n10:nanoparticles n10:precipitation n10:steroids n10:excipients
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[A8947A4A0A0F]
n3:nazevZdroje
Molecules
n3:obor
n15:CA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:projekt
n4:GAP304%2F11%2F2246
n3:rokUplatneniVysledku
n6:2012
n3:svazekPeriodika
17
n3:tvurceVysledku
Grünwaldová, Veronika Král, V. Dohnal, J. Vaculíková, E. Jampílek, J.
n3:wos
000309269700074
s:issn
1420-3049
s:numberOfPages
12
n12:doi
10.3390/molecules170911067