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Statements

Subject Item
n2:RIV%2F61388980%3A_____%2F12%3A00383643%21RIV13-AV0-61388980
rdf:type
n7:Vysledek skos:Concept
dcterms:description
A synthesis of the first double-decker sandwich ion [(1,2-C 2B 9H 11)-3,3-Co-(1,2-C 2B 8H 10)-6,3“-Co-(1“,2“-C 2B 9H 11)] 2- (DD 2-) derivatives is described, having been developed in connection with our search for biologically active substances. A series of B-substituted hydroxyl derivatives was prepared by direct hydroxylation of the ion using aqueous sulfuric acid. Two isomers of monohydroxy derivatives were isolated. The main product was substituted at the central 'canastide' ion fragment, whereas the substitution site for the minor isomer corresponded to a B(8) atom of one of the terminal 11-vertex dicarbollide parts. Similarly, the disubstitution occurred slightly more preferentially on the canastide fragment providing the main isomeric derivative with a symmetric structure. The cesium salt of this ion was characterized by X-ray diffraction. Two other isomeric species have one substituent sitting on the canastide ion and the second present on the dicarbollide ligand in apart or syn-geometric arrangement. A new zwitterion anion [(1,2-C 2B 9H 11)-3,3-Co-(8-(CH 2) 4O-1,2-C 2B 8H 9)-6,3“-Co-(1“,2“-C 2B 9H 11)-] 1- was prepared by the reaction of the parent ion with tetrahydrofuran (THF), activated by BF 3OEt 2. This new compound serves as a versatile building block for constructing organic derivatives, as exemplified by the ring cleavage by various amines or phenolate ions and the synthesis of a basic series of compounds of general formulation [(1,2-C 2B 9H 11)-3,3-Co-(8-X-(CH 2) 4O-1,2-C 2B 8H 9)-6,3“-Co-(1“,2“-C 2B 9H 11)] n- where the organic end-groups X adjacent to the canastide moiety via a B-oxatetramethylene spacer corresponds to C 4H 9NH 2, NC 5H 2, N(C 2H 5) 3, (C 6H 5) 3P (n = 1), or (4-t-Bu-C 6H 4-1-O)- and (2-CH 3O-C 6H 4O) - (n = 2). . All compounds were characterized by high-resolution NMR ( 1H, 13C, and 11B) and mass spectrometry. A synthesis of the first double-decker sandwich ion [(1,2-C 2B 9H 11)-3,3-Co-(1,2-C 2B 8H 10)-6,3“-Co-(1“,2“-C 2B 9H 11)] 2- (DD 2-) derivatives is described, having been developed in connection with our search for biologically active substances. A series of B-substituted hydroxyl derivatives was prepared by direct hydroxylation of the ion using aqueous sulfuric acid. Two isomers of monohydroxy derivatives were isolated. The main product was substituted at the central 'canastide' ion fragment, whereas the substitution site for the minor isomer corresponded to a B(8) atom of one of the terminal 11-vertex dicarbollide parts. Similarly, the disubstitution occurred slightly more preferentially on the canastide fragment providing the main isomeric derivative with a symmetric structure. The cesium salt of this ion was characterized by X-ray diffraction. Two other isomeric species have one substituent sitting on the canastide ion and the second present on the dicarbollide ligand in apart or syn-geometric arrangement. A new zwitterion anion [(1,2-C 2B 9H 11)-3,3-Co-(8-(CH 2) 4O-1,2-C 2B 8H 9)-6,3“-Co-(1“,2“-C 2B 9H 11)-] 1- was prepared by the reaction of the parent ion with tetrahydrofuran (THF), activated by BF 3OEt 2. This new compound serves as a versatile building block for constructing organic derivatives, as exemplified by the ring cleavage by various amines or phenolate ions and the synthesis of a basic series of compounds of general formulation [(1,2-C 2B 9H 11)-3,3-Co-(8-X-(CH 2) 4O-1,2-C 2B 8H 9)-6,3“-Co-(1“,2“-C 2B 9H 11)] n- where the organic end-groups X adjacent to the canastide moiety via a B-oxatetramethylene spacer corresponds to C 4H 9NH 2, NC 5H 2, N(C 2H 5) 3, (C 6H 5) 3P (n = 1), or (4-t-Bu-C 6H 4-1-O)- and (2-CH 3O-C 6H 4O) - (n = 2). . All compounds were characterized by high-resolution NMR ( 1H, 13C, and 11B) and mass spectrometry.
dcterms:title
Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances
skos:prefLabel
Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances Derivatization chemistry of the double-decker dicobalt sandwich ion targeted to design biologically active substances
skos:notation
RIV/61388980:_____/12:00383643!RIV13-AV0-61388980
n7:predkladatel
n15:ico%3A61388980
n3:aktivita
n16:P n16:I
n3:aktivity
I, P(IAAX00320901)
n3:cisloPeriodika
11
n3:dodaniDat
n14:2013
n3:domaciTvurceVysledku
n13:3587002 n13:3617882 n13:5578221
n3:druhVysledku
n17:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
130187
n3:idVysledku
RIV/61388980:_____/12:00383643
n3:jazykVysledku
n10:eng
n3:klicovaSlova
AIDS treatment; boranes; canastide ion; carboranes; dicarbollides; HIV-protease
n3:klicoveSlovo
n6:AIDS%20treatment n6:boranes n6:canastide%20ion n6:carboranes n6:HIV-protease n6:dicarbollides
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[17A56391A20B]
n3:nazevZdroje
Pure and Applied Chemistry
n3:obor
n9:CA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n18:IAAX00320901
n3:rokUplatneniVysledku
n14:2012
n3:svazekPeriodika
84
n3:tvurceVysledku
Konvalinka, Jan Grüner, Bohumír Švec, Petr Císařová, I. Pokorná, Jana Hájková, Zuzana
n3:wos
000311631700006
s:issn
0033-4545
s:numberOfPages
20
n12:doi
10.1351/PAC-CON-12-04-03