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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F14%3A00439960%21RIV15-GA0-61388971
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Nucleus movement, positioning, and orientation is precisely specified and actively regulated within cells, and it plays a critical role in many cellular and developmental processes. Mutation of proteins that regulate the nucleus anchoring and movement lead to diverse pathologies, laminopathies in particular, suggesting that the nucleus correct positioning and movement is essential for proper cellular function. In motile cells that polarize toward the direction of migration, the nucleus undergoes controlled rotation promoting the alignment of the nucleus with the axis of migration. Such spatial organization of the cell appears to be optimal for the cell migration. Nuclear reorientation requires the cytoskeleton to be anchored to the nuclear envelope, which exerts pulling or pushing torque on the nucleus. Here we discuss the possible molecular mechanisms regulating the nuclear rotation and reorientation and the significance of this type of nuclear movement for cell migration. Nucleus movement, positioning, and orientation is precisely specified and actively regulated within cells, and it plays a critical role in many cellular and developmental processes. Mutation of proteins that regulate the nucleus anchoring and movement lead to diverse pathologies, laminopathies in particular, suggesting that the nucleus correct positioning and movement is essential for proper cellular function. In motile cells that polarize toward the direction of migration, the nucleus undergoes controlled rotation promoting the alignment of the nucleus with the axis of migration. Such spatial organization of the cell appears to be optimal for the cell migration. Nuclear reorientation requires the cytoskeleton to be anchored to the nuclear envelope, which exerts pulling or pushing torque on the nucleus. Here we discuss the possible molecular mechanisms regulating the nuclear rotation and reorientation and the significance of this type of nuclear movement for cell migration.
dcterms:title
Emerging role for nuclear rotation and orientation in cell migration Emerging role for nuclear rotation and orientation in cell migration
skos:prefLabel
Emerging role for nuclear rotation and orientation in cell migration Emerging role for nuclear rotation and orientation in cell migration
skos:notation
RIV/61388971:_____/14:00439960!RIV15-GA0-61388971
n3:aktivita
n13:I n13:P
n3:aktivity
I, P(GA204/09/0614)
n3:cisloPeriodika
1
n3:dodaniDat
n4:2015
n3:domaciTvurceVysledku
n11:3252841 n11:3963926
n3:druhVysledku
n15:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
14399
n3:idVysledku
RIV/61388971:_____/14:00439960
n3:jazykVysledku
n14:eng
n3:klicovaSlova
cell polarity; actin; migration; microtubules
n3:klicoveSlovo
n10:actin n10:migration n10:cell%20polarity n10:microtubules
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[12F943BC6D18]
n3:nazevZdroje
Cell Adhesion and Migration
n3:obor
n16:EE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n12:GA204%2F09%2F0614
n3:rokUplatneniVysledku
n4:2014
n3:svazekPeriodika
8
n3:tvurceVysledku
Maninová, Miloslava Iwanicki, M. P. Vomastek, Tomáš
n3:wos
000332460300007
s:issn
1933-6918
s:numberOfPages
7