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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F14%3A00433022%21RIV15-GA0-61388971
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Immunocompatibility of gelatin-based hydrogels to be applied as implant coatings for local regenerative treatment has been studied. First, the bio- and immuno-acceptability of the methacrylamide-modified gelatin hydrogels per se was screened. The results indicated that the hydrogels support cell growth. Metabolic activity of normal cells and permanent cell lines representing various cell types (endothelial, epithelial, fibroblast, and monocyte/macrophage) cultivated on the gelatin hydrogels was moderately lower compared to cells cultivated on tissue culture plastic. The cells cultivated on the hydrogels produced identical cytokines as the control cells although at lower levels. Importantly, no inflammatory activity, measured by nitric oxide and pro-inflammatory cytokine (IL-1, IL-6, and TNF) production, was observed in peritoneal cells and monocyte/macrophage RAW 264.7 cell line cultivated on the hydrogels Immunocompatibility of gelatin-based hydrogels to be applied as implant coatings for local regenerative treatment has been studied. First, the bio- and immuno-acceptability of the methacrylamide-modified gelatin hydrogels per se was screened. The results indicated that the hydrogels support cell growth. Metabolic activity of normal cells and permanent cell lines representing various cell types (endothelial, epithelial, fibroblast, and monocyte/macrophage) cultivated on the gelatin hydrogels was moderately lower compared to cells cultivated on tissue culture plastic. The cells cultivated on the hydrogels produced identical cytokines as the control cells although at lower levels. Importantly, no inflammatory activity, measured by nitric oxide and pro-inflammatory cytokine (IL-1, IL-6, and TNF) production, was observed in peritoneal cells and monocyte/macrophage RAW 264.7 cell line cultivated on the hydrogels
dcterms:title
Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine
skos:prefLabel
Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine
skos:notation
RIV/61388971:_____/14:00433022!RIV15-GA0-61388971
n3:aktivita
n14:I n14:P
n3:aktivity
I, P(GAP301/12/1254)
n3:cisloPeriodika
6
n3:dodaniDat
n18:2015
n3:domaciTvurceVysledku
n11:1208241 n11:1130706 n11:8721386
n3:druhVysledku
n16:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
20538
n3:idVysledku
RIV/61388971:_____/14:00433022
n3:jazykVysledku
n17:eng
n3:klicovaSlova
methacrylamide-modified gelatin; hydrogel; polyimide implant
n3:klicoveSlovo
n8:hydrogel n8:polyimide%20implant n8:methacrylamide-modified%20gelatin
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[7DECFE2256CB]
n3:nazevZdroje
Journal of Biomedical Materials Research. Part A
n3:obor
n4:EC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
7
n3:projekt
n12:GAP301%2F12%2F1254
n3:rokUplatneniVysledku
n18:2014
n3:svazekPeriodika
102
n3:tvurceVysledku
Schacht, E. Říhová, Blanka Matyášová, V. Šírová, Milada Dubruel, P. Rossmann, Pavel van Vlierberghe, S.
n3:wos
000334488800036
s:issn
1549-3296
s:numberOfPages
9
n9:doi
10.1002/jbm.a.34873