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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F14%3A00433017%21RIV15-GA0-61388971
rdf:type
n6:Vysledek skos:Concept
dcterms:description
The flavonoid isoquercitrin (quercetin-3-O-beta-D-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and %22enzymatically modified (alpha-glucosylated) isoquercitrin%22 (EMIQ). Pure isoquercitrin can now be obtained on a large scale by enzymatic rutin hydrolysis with alpha-L-rhamnosidase. Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes and allergic reactions. Although small amounts of intact isoquercitrin can be found in plasma and tissues after oral application, it is extensively metabolized in the intestine and the liver The flavonoid isoquercitrin (quercetin-3-O-beta-D-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and %22enzymatically modified (alpha-glucosylated) isoquercitrin%22 (EMIQ). Pure isoquercitrin can now be obtained on a large scale by enzymatic rutin hydrolysis with alpha-L-rhamnosidase. Isoquercitrin has higher bioavailability than quercetin and displays a number of chemoprotective effects both in vitro and in vivo, against oxidative stress, cancer, cardiovascular disorders, diabetes and allergic reactions. Although small amounts of intact isoquercitrin can be found in plasma and tissues after oral application, it is extensively metabolized in the intestine and the liver
dcterms:title
Isoquercitrin: Pharmacology, toxicology, and metabolism Isoquercitrin: Pharmacology, toxicology, and metabolism
skos:prefLabel
Isoquercitrin: Pharmacology, toxicology, and metabolism Isoquercitrin: Pharmacology, toxicology, and metabolism
skos:notation
RIV/61388971:_____/14:00433017!RIV15-GA0-61388971
n3:aktivita
n4:P n4:I
n3:aktivity
I, P(7E11011), P(GAP301/11/0767), P(GBP303/12/G163), P(LD13041)
n3:cisloPeriodika
JUN 2014
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n10:3973654 n10:5894190
n3:druhVysledku
n9:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
22968
n3:idVysledku
RIV/61388971:_____/14:00433017
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Quercetin-3-glucoside; Quercetin-3-O-beta-D-glucopyranoside; Enzymatically modified isoquercitrin
n3:klicoveSlovo
n14:Enzymatically%20modified%20isoquercitrin n14:Quercetin-3-glucoside n14:Quercetin-3-O-beta-D-glucopyranoside
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[8D63081E178F]
n3:nazevZdroje
Food and Chemical Toxicology
n3:obor
n13:CE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:projekt
n5:LD13041 n5:GAP301%2F11%2F0767 n5:7E11011 n5:GBP303%2F12%2FG163
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
68
n3:tvurceVysledku
Křen, Vladimír Ulrichová, J. Valentová, Kateřina Vrba, J. Bancířová, M.
n3:wos
000337653000029
s:issn
0278-6915
s:numberOfPages
16
n18:doi
10.1016/j.fct.2014.03.018