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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F13%3A00395423%21RIV14-MSM-61388971
rdf:type
n14:Vysledek skos:Concept
dcterms:description
The glycan code of glycoproteins can be conceptually defined at molecular level by the sequence of well characterized glycans attached to evolutionarily predetermined amino acids along the polypeptide chain. Functional consequences of protein glycosylation are numerous, and include a hierarchy of properties from general physicochemical characteristics such as solubility, stability and protection of the polypeptide from the environment up to specific glycan interactions. Definition of the glycan code for glycoproteins has been so far hampered by the lack of chemically defined glycoprotein glycoforms that proved to be extremely difficult to purify from natural sources, and the total chemical synthesis of which has been hitherto possible only for very small molecular species The glycan code of glycoproteins can be conceptually defined at molecular level by the sequence of well characterized glycans attached to evolutionarily predetermined amino acids along the polypeptide chain. Functional consequences of protein glycosylation are numerous, and include a hierarchy of properties from general physicochemical characteristics such as solubility, stability and protection of the polypeptide from the environment up to specific glycan interactions. Definition of the glycan code for glycoproteins has been so far hampered by the lack of chemically defined glycoprotein glycoforms that proved to be extremely difficult to purify from natural sources, and the total chemical synthesis of which has been hitherto possible only for very small molecular species
dcterms:title
Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances
skos:prefLabel
Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances
skos:notation
RIV/61388971:_____/13:00395423!RIV14-MSM-61388971
n14:predkladatel
n16:ico%3A61388971
n3:aktivita
n19:P n19:I
n3:aktivity
I, P(7E11011), P(GA303/09/0477), P(GAP207/10/0321), P(GD305/09/H008), P(LD13041)
n3:cisloPeriodika
1
n3:dodaniDat
n8:2014
n3:domaciTvurceVysledku
n9:6883753 n9:8710740 n9:2100592 n9:2491842 n9:8732124 n9:3895831
n3:druhVysledku
n18:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
64255
n3:idVysledku
RIV/61388971:_____/13:00395423
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Cellular factories; Complex carbohydrates; Glycodrugs
n3:klicoveSlovo
n12:Glycodrugs n12:Complex%20carbohydrates n12:Cellular%20factories
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[CCF905E24AF2]
n3:nazevZdroje
Biotechnology Advances
n3:obor
n6:CE
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n4:GD305%2F09%2FH008 n4:LD13041 n4:GA303%2F09%2F0477 n4:7E11011 n4:GAP207%2F10%2F0321
n3:rokUplatneniVysledku
n8:2013
n3:svazekPeriodika
31
n3:tvurceVysledku
Vaněk, Ondřej Novák, Petr Bezouška, Karel Bojarová, Pavla Weignerová, Lenka Mrázek, Hynek
n3:wos
000315761200003
s:issn
0734-9750
s:numberOfPages
21
n10:doi
10.1016/j.biotechadv.2012.03.008