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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F12%3A00386940%21RIV13-GA0-61388971
rdf:type
n11:Vysledek skos:Concept
dcterms:description
VDJ and VJ rearrangements, expression of RAG-1, Tdt and VpreB, and the presence of signal joint circles (SJC) were used to identify sites of B-cell lymphogenesis. VDJ, V?J? but not V?J? rearrangements or SJC were recovered from yolk sac (YS) at 20 similar to days of gestation (DG) along with strong expression of VpreB and RAG-1 but weak Tdt expression. V?J? rearrangements but not V?J? rearrangements were recovered from fetal liver at 3050 DG. SJC were pronounced in bone marrow at 95 DG where V?J? rearrangements were first recovered. The V?J? rearrangements recovered at 2050 DG used some of the same V? and J? segments seen in older fetuses and adult animals. Hence the textbook paradigm for the order of light-chain rearrangement does not apply to swine. Consistent with weak Tdt expression in early sites of lymphogenesis, N-region additions in VDJ rearrangements were more frequent at 95 DG. Junctional diversity in V?J? rearrangement was limited at all stages of development. There was little evidence for B-cell lymphogenesis in the ileal Peyer's patches. The widespread recovery of VpreB transcripts in whole, non-lymphoid tissue was unexpected as was its recovery from bone marrow and peripheral blood monocytes. Based on recovery of SJC, B-cell lymphogenesis continues for at least 5 similar to weeks postpartum VDJ and VJ rearrangements, expression of RAG-1, Tdt and VpreB, and the presence of signal joint circles (SJC) were used to identify sites of B-cell lymphogenesis. VDJ, V?J? but not V?J? rearrangements or SJC were recovered from yolk sac (YS) at 20 similar to days of gestation (DG) along with strong expression of VpreB and RAG-1 but weak Tdt expression. V?J? rearrangements but not V?J? rearrangements were recovered from fetal liver at 3050 DG. SJC were pronounced in bone marrow at 95 DG where V?J? rearrangements were first recovered. The V?J? rearrangements recovered at 2050 DG used some of the same V? and J? segments seen in older fetuses and adult animals. Hence the textbook paradigm for the order of light-chain rearrangement does not apply to swine. Consistent with weak Tdt expression in early sites of lymphogenesis, N-region additions in VDJ rearrangements were more frequent at 95 DG. Junctional diversity in V?J? rearrangement was limited at all stages of development. There was little evidence for B-cell lymphogenesis in the ileal Peyer's patches. The widespread recovery of VpreB transcripts in whole, non-lymphoid tissue was unexpected as was its recovery from bone marrow and peripheral blood monocytes. Based on recovery of SJC, B-cell lymphogenesis continues for at least 5 similar to weeks postpartum
dcterms:title
Antibody repertoire development in fetal and neonatal piglets. XXII. lambda rearrangement precedes kappa rearrangement during B-cell lymphogenesis in swine Antibody repertoire development in fetal and neonatal piglets. XXII. lambda rearrangement precedes kappa rearrangement during B-cell lymphogenesis in swine
skos:prefLabel
Antibody repertoire development in fetal and neonatal piglets. XXII. lambda rearrangement precedes kappa rearrangement during B-cell lymphogenesis in swine Antibody repertoire development in fetal and neonatal piglets. XXII. lambda rearrangement precedes kappa rearrangement during B-cell lymphogenesis in swine
skos:notation
RIV/61388971:_____/12:00386940!RIV13-GA0-61388971
n11:predkladatel
n18:ico%3A61388971
n3:aktivita
n16:I n16:P
n3:aktivity
I, P(GAP502/10/0038), P(ME09089)
n3:cisloPeriodika
2
n3:dodaniDat
n6:2013
n3:domaciTvurceVysledku
n10:1832190 n10:6304206
n3:druhVysledku
n15:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
122909
n3:idVysledku
RIV/61388971:_____/12:00386940
n3:jazykVysledku
n12:eng
n3:klicovaSlova
B-cell lymphogenesis; fetal; RAG-1
n3:klicoveSlovo
n14:RAG-1 n14:fetal n14:B-cell%20lymphogenesis
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[90E769F05BDE]
n3:nazevZdroje
Immunology
n3:obor
n5:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:projekt
n13:GAP502%2F10%2F0038 n13:ME09089
n3:rokUplatneniVysledku
n6:2012
n3:svazekPeriodika
137
n3:tvurceVysledku
Lager, K. Šinkora, Marek Štěpánová, Kateřina Wertz, N. Sun, X. Tobin, G. Butler, J. E.
n3:wos
000308405700005
s:issn
0019-2805
s:numberOfPages
11
n7:doi
10.1111/j.1365-2567.2012.03615.x