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Statements

Subject Item
n2:RIV%2F61388971%3A_____%2F12%3A00379000%21RIV13-GA0-61388971
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Copolymers of hydroxyethyl methacrylate and styrene sulfonate complex with isolated gliadin (the toxic fraction of gluten) and prevent damage to the intestinal barrier in HLA-HCD4/DQ8 mice. We studied the activity toward gluten and hordein digestion and biologic effects of poly(hydroxyethyl methacrylate-co-styrene sulfonate (P(HEMA-co-SS)). We also investigated the effect of gliadin complex formation in intestinal biopsy specimens from patients with celiac disease. METHODS: We studied the ability of P(HEMA-co-SS) to reduce digestion of wheat gluten and barley hordein into immunotoxic peptides using liquid chromatography-mass spectrometry Copolymers of hydroxyethyl methacrylate and styrene sulfonate complex with isolated gliadin (the toxic fraction of gluten) and prevent damage to the intestinal barrier in HLA-HCD4/DQ8 mice. We studied the activity toward gluten and hordein digestion and biologic effects of poly(hydroxyethyl methacrylate-co-styrene sulfonate (P(HEMA-co-SS)). We also investigated the effect of gliadin complex formation in intestinal biopsy specimens from patients with celiac disease. METHODS: We studied the ability of P(HEMA-co-SS) to reduce digestion of wheat gluten and barley hordein into immunotoxic peptides using liquid chromatography-mass spectrometry
dcterms:title
The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues
skos:prefLabel
The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues
skos:notation
RIV/61388971:_____/12:00379000!RIV13-GA0-61388971
n7:predkladatel
n17:ico%3A61388971
n4:aktivita
n14:P n14:Z
n4:aktivity
P(GA310/07/0414), Z(AV0Z50200510)
n4:cisloPeriodika
2
n4:dodaniDat
n19:2013
n4:domaciTvurceVysledku
n15:8333734 n15:5461286
n4:druhVysledku
n10:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
128792
n4:idVysledku
RIV/61388971:_____/12:00379000
n4:jazykVysledku
n12:eng
n4:klicovaSlova
Polymeric Binders; Gluten Intolerance; Autoimmune Disorder
n4:klicoveSlovo
n11:Gluten%20Intolerance n11:Polymeric%20Binders n11:Autoimmune%20Disorder
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[7219F8A74CD4]
n4:nazevZdroje
Gastroenterology
n4:obor
n5:EC
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
10
n4:projekt
n8:GA310%2F07%2F0414
n4:rokUplatneniVysledku
n19:2012
n4:svazekPeriodika
142
n4:tvurceVysledku
Verdu, E. F. Rivard, N. Drašarová, Hana Galipeau, H. J. Pinier, M. Fuhrmann, G. Leroux, J. Ch. Murray, J. A. Tučková, Ludmila David, Ch. S.
n4:wos
000299540000038
n4:zamer
n20:AV0Z50200510
s:issn
0016-5085
s:numberOfPages
10
n18:doi
10.1053/j.gastro.2011.10.038